54 citations
,
January 2016 in “Cell reports” This study found that different epidermal stem cell populations contribute to the formation of various skin tumors and new hair follicles following β-catenin activation in the adult epidermis.
29 citations
,
January 2021 in “G3 Genes Genomes Genetics” This study identified a 195 bp duplication in crested chickens that causes large crest feathers and can be associated with cerebral hernia in some breeds, but not all.
29 citations
,
December 2004 in “Developmental biology” In this study, forced expression of the transcription factor cDermo-1 in chicken dermis led to the formation of ectopic feather buds and enhanced feather growth, demonstrating its role in initiating skin appendage development.
21 citations
,
June 2016 in “Genesis” This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.
17 citations
,
May 2018 in “BMC genomics” This study found that miR-432 inhibits KRT83 expression, revealing potential molecular mechanisms for the formation of curly fleece in Tan sheep and suggesting implications for understanding curly hair formation in humans.
9 citations
,
March 2015 in “International reviews of immunology” This review discusses the relationship between ectodermal alterations and immunodeficiencies, particularly the roles of hyper-IgE syndrome, ectodermal dysplasia, and FOXN1 gene mutations, but it presents no new research findings.
8 citations
,
January 2015 in “Genetics and molecular research” This study identified four proteins that differ between Type III and non-Type III hair in Yangtze River Delta white goats, contributing to understanding the development of high-quality brush hair.
May 2026 in “Scientific Reports” In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.
May 2026 in “The EMBO Journal” This study demonstrated how cellular flows and tissue mechanics guide the topological transformations in avian skin, essential for feather follicle development from scales.
June 2023 in “Frontiers in Medicine” This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.
January 2022 in “Springer eBooks” This review discusses the potential of the hair follicle dermis to direct hair development and explores concepts related to hair growth and androgenetic alopecia, without reporting new clinical results.
This study found that Nubian ibex have developed genetic adaptations in response to their desert environment, including enhanced skin barrier, DNA repair, viral response, and metabolism of toxic compounds.
1 citations
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December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that manipulating Wnt/β-catenin signaling in embryonic mammary glands impacted their development, with high activity levels hindering branching and potentially redirecting cells toward hair follicle identity instead of mammary tissue.
May 2014 in “The journal of immunology/The Journal of immunology” In this study, over-expression of FoxN1 in early life was associated with detrimental effects on thymic and skin epithelial development in mice.
April 2026 in “IntechOpen eBooks” The researchers presented a case study on Exo.Reset®, a cosmetic formulation using extracellular vesicle technology, demonstrating systematic application of recognized standards to ensure scientific rigor and regulatory compliance in skin rejuvenation product development, providing a practical model for EV-based cosmetic innovations.
December 2024 in “Здобутки клінічної і експериментальної медицини” This study reviews current research on skin repair and regeneration, highlighting promising methods such as stem cell therapies, nanotechnology, and skin substitutes, which may enhance healing and resistance to environmental damage.
November 2024 in “Comparative Biochemistry and Physiology Part D Genomics and Proteomics” In this study, epithelial cell-derived exosomes promoted fibroblast migration and inhibited their proliferation, suggesting a role in dermal condensate formation and hair follicle morphogenesis in cashmere goats.
November 2021 in “Current Otorhinolaryngology Reports” New treatments for hair loss could involve using stem cells and a process called the Wnt/beta-catenin pathway to stimulate hair growth.
This review examines the development of research on the role of the Wnt signaling pathway in the epidermal repair process and reports no new experimental findings.
171 citations
,
June 2004 in “Journal of Investigative Dermatology” GLI2 activates GLI1, promoting skin tumor growth and hair development.
127 citations
,
April 1999 in “Journal of Investigative Dermatology” This review compares various rodent models that reflect aspects of psoriasis with human psoriasis and potential applications for research, reporting no new clinical findings.
100 citations
,
May 2006 in “American Journal Of Pathology” Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.
39 citations
,
January 2013 in “Journal of Investigative Dermatology” This review explains how recent understanding of Wnt signaling regulation in hair follicles could potentially be used to enhance hair growth, but it reports no new empirical results.
30 citations
,
March 2007 in “Expert opinion on drug safety” This review discusses recommendations for managing cetuximab-induced rash in metastatic colorectal cancer treatment and highlights the lack of standardized treatment plans based on clinical evidence.
22 citations
,
January 2009 in “Advances in experimental medicine and biology” This review discusses the human Nude/SCID phenotype and FOXN1 gene's role in immunological disorders affecting T-cell development but reports no new clinical findings.
16 citations
,
April 2021 in “International Journal of Molecular Sciences” This study found that micro-current electrical stimulation may promote hair growth in human hair follicle-derived papilla cells and a mice model by enhancing cell proliferation, migration, and activating key growth pathways.
11 citations
,
August 2014 in “PLoS ONE” This study found that GFRα2 influences cell size but not survival or target innervation of Ret-positive low-threshold mechanoreceptors in mouse dorsal root ganglia, differing from its role in nonpeptidergic nociceptors.
9 citations
,
May 2023 in “Stem Cell Research & Therapy” This study found that mesenchymal stem cell treatment alleviated atopic dermatitis-like symptoms in a mouse model by modulating immune and inflammatory responses, with gene expression changes suggesting pathways for potential personalized treatment approaches.
7 citations
,
February 2018 in “Journal of Investigative Dermatology” This study investigates the role of peroxisome proliferator-activated receptor gamma in hair follicle morphogenesis using a novel mouse model but reports no new results, highlighting the need for further research on its function during the hair cycle.
7 citations
,
March 2005 in “Journal of dermatological science” This study found that apoptosis, along with proliferation, plays a crucial role in shaping and extending human hair follicles by coordinating the formation and differentiation of the hair canal.