February 2015 in “Journal of Biomedical Materials Research Part B: Applied Biomaterials” This study suggests that 4-META resin may be more effective than cyanoacrylate for promoting wound healing in rats, as the wounds were covered by epithelial tissue faster with 4-META resin.
125 citations
,
August 2003 in “Development” In this study, mice engineered to express human EGFR showed tissue-specific growth defects and neurodegeneration rescue, but developed severe heart issues and accelerated bone cell differentiation.
75 citations
,
January 2011 in “Plastic and Reconstructive Surgery” This review discusses the use of dermal regeneration templates for treating burn injuries and other wounds, highlighting their effectiveness in reducing scars and aiding in regenerative processes, but reports no new clinical results.
11 citations
,
March 2004 in “Journal of Comparative Pathology” Norfolk Terriers have a genetic skin defect causing scaling and blisters due to a keratin issue.
10 citations
,
May 2009 in “Journal of The American Academy of Dermatology” This case report describes a dual transposition flap technique for closing large scalp defects post-Mohs surgery, achieving minimal alopecia and scar visibility, though it is based on a single patient.
3 citations
,
August 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” The technique effectively repairs skin after tumor removal, maintaining appearance and function without complications.
July 2012 in “Dermatologic Surgery” The author believes artificial dermis might not be the best first option for hair transplant surgeons when other surgical choices exist for scalp reconstruction.
November 2023 in “Indian journal of surgery” This study found that platelet-rich gel is a simple and effective non-surgical method for healing exposed skull injuries, resulting in complete healing with minimal scars and sparse hair growth in all patients.
June 2008 in “The Knowledge Bank (The Ohio State University)” This study found that deleting Smad2 and Smad3 in murine skin leads to severe skin abnormalities and cancerous lesions, similar to but more severe than those seen in Smad4 mutants, indicating the critical role of TGF-β signaling in skin development.
89 citations
,
March 1996 in “Proceedings of the National Academy of Sciences” This study found that homozygous mutant mice with a hypomorphic CD18 mutation developed a chronic inflammatory skin disease resembling human psoriasis, potentially implicating additional genetic factors in disease susceptibility.
5 citations
,
August 2011 in “Dermatologic Surgery” Artificial dermis used for hair transplantation can reconstruct scalp defects effectively without the need for tissue expansion.
1 citations
,
August 2015 in “Experimental Dermatology” This review discusses the roles of KIT and mast cells in skin physiology and pathology using different genetic models and reports no new clinical results; the authors suggest further exploration of KIT deficiency.
January 2014 in “Max Planck Digital Library” This research describes mouse models to explore Kindlin-1's role in skin disorders, including Kindler syndrome, revealing novel integrin-independent pathways potentially leading to skin tumors.
March 2026 in “Experimental Dermatology” This study developed an in vitro model using NTERT keratinocytes expressing AEC-related TP63 mutations, which replicated skin defects observed in AEC patients and offers a valuable tool for understanding the disorder and developing new treatments.
25 citations
,
November 2014 in “Ageing Research Reviews” This review discusses the mechanisms of skin aging, highlighting the roles of stem/progenitor cells, genetic and environmental factors, and suggests potential for cell-based therapies, but reports no new experimental findings.
May 2026 in “JID Innovations” This study found a significant overlap between gene expression signatures of alopecia areata and certain chronic inflammatory skin disorders, suggesting shared biological processes may drive their co-occurrence and providing a foundation for future research into distinct comorbid subtypes.
This study suggests that the exercise-induced cytokine IL-15 can improve wound healing in aged skin, along with previously reported benefits on skin structure and mitochondrial function.
6 citations
,
June 2016 in “Journal of Craniofacial Surgery” This study reports that using a combined approach of free osteoseptocutaneous fibula flap and temporal artery-based scalp flap provided satisfactory aesthetic and functional outcomes in reconstructing gunshot-inflicted composite mandibular defects in males.
41 citations
,
December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.
26 citations
,
February 2011 in “Journal of Plastic Reconstructive and Aesthetic Surgery” Technique effectively treats deformities, achieves re-pigmentation, and releases scar contractures.
12 citations
,
July 2015 in “Experimental Dermatology” This study found that overexpression of Gsdma3 in mice led to epidermal hyperplasia, skin inflammation, and hair growth defects, suggesting gain-of-function mutations in Gsdma3 cause these conditions.
3 citations
,
March 1956 in “PubMed” This study discusses a surgical skin planing procedure using new technology and freezing agent that is reported to be a safe, effective treatment for cutaneous defects like pitted acne scars.
April 2010 in “The journal of immunology/The Journal of immunology” This study found that deleting the FoxN1 gene in mice disrupted the 3D thymic epithelial structure and led to 2D epithelial cysts, revealing its crucial role in thymus organization but not causing athymia.
1 citations
,
October 2008 in “PubMed” This review highlights advancements in skin tissue engineering in China over the past 20 years and reports no new clinical findings, noting future potential for artificial skin in burn treatment.
December 2024 in “Regenerative Therapy” This study review found that stem cells can be transformed into normal skin cells and skin organoids, offering promising methods for regenerating skin integrity and advancing both basic and clinical skin biology research.
21 citations
,
November 2010 in “Journal of molecular medicine” This study found that deleting FoxN1 in specific thymic epithelial cells disrupted the 3D thymic structure and led to age-dependent formation of 2D epithelial cysts, highlighting FoxN1's critical role in thymic morphogenesis.
3 citations
,
April 2016 in “Dermatologic Surgery” This abstract provides author contact details but presents no study findings or results.
In this retrospective analysis, researchers evaluated 54 patients undergoing soft tissue reconstruction for scalp and forehead defects and reported excellent aesthetic outcomes with local flaps for defects up to 50 cm², while larger defects typically required additional skin grafting.
June 2017 in “International Journal of Periodontics & Restorative Dentistry” This study found that using retroauricular full-thickness skin grafts in vestibuloplasty contributed to successful cosmetic and functional outcomes in dental implant rehabilitation for patients with mandibular gunshot injuries.
This chapter reviews fungal skin diseases in cattle and reports no new findings; the authors discuss conditions like sterile eosinophilic folliculitis and anagen defluxion, noting their patterns and effects.