Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, researchers investigated changes in ribosomal RNA modifications associated with stress-induced cellular senescence in human skin cells, identifying potential biomarkers and targets for interventions to mitigate skin aging.

This study found that blocking apoptosis during the catagen phase in mice disrupts hair follicle stem cell niche architecture, delaying subsequent hair regeneration cycles.

This study found that ultraviolet radiation negatively affects hair follicle functions in human scalp skin, and caffeine application may provide some protective effects against this damage.

This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.

This study used digital-light-processing bioprinting to create a 3D skin-on-a-chip model with a miniaturized vascular network to closely study immune cell interactions similar to real human skin, demonstrating the potential to analyze immune-T cell trafficking influenced by skin signals.

This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.

This study found that Bcl-xL deficiency in mice increased apoptosis and resistance to skin tumor development, highlighting Bcl-xL's role in early skin carcinogenesis through anti-apoptotic functions.

This study explored IL-17D's role in skin biology and found no significant difference in disease progression between IL-17D KO and WT mice in skin inflammation models, but IL-17D did promote cell migration and modestly accelerated wound healing, suggesting it may influence tissue repair processes.

Collagen scaffolds in cell therapy can transform skin to be more resilient and pressure-responsive.

This review highlights that the epidermis acts as an endocrine organ, synthesizing and responding to hormones such as corticosteroids and Vitamin D, impacting processes like hair growth and immune response, and participating in regulating endocrine balance.

This review discusses how combining single-cell RNA sequencing and 3D bioprinting is advancing skin tissue engineering by enhancing cellular-level precision and addressing challenges like vascularization, ultimately improving regenerative outcomes and therapeutic strategies.

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.

This article reviews the emerging non-inflammatory roles of regulatory T cells in the skin and reports no new clinical findings, suggesting broad biological influence beyond traditional immune functions.

The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

This study found that in a mouse model of psoriasis, depleting CD169⁺ macrophages led to milder symptoms and decreased inflammation, suggesting these macrophages play a crucial role in psoriasis development.

This study found significant upregulation of IDO-1 and IDO-2 in human basal cell carcinomas, suggesting that IDO production may confer immune privilege characteristics to the tumors, potentially impacting their growth.

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This review discusses multiple pathways through which exosomes may regulate skin functions and diseases like melanoma, scleroderma, and pigmentation disorders, without providing new clinical results; future therapeutic strategies are suggested.

This review highlights that collagen XVIIα1's role in maintaining dermal-epidermal junction integrity and hair follicle stem cell maintenance is compromised with age due to reduced levels and increased processing, potentially affecting skin and hair aging.

This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.

Collagen XVIII and Bmx tyrosine kinase are important for hair growth and skin cancer development.

This study found that skin-derived precursor cells in mice can originate from both neural crest and somite lineages but show functional similarities regardless of their developmental origins.

This study developed a method to convert fibroblasts into sweat gland-like cells, suggesting potential for regenerating damaged skin and restoring sweat gland function.

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

In this study, researchers used advanced techniques to map the early embryonic development of mouse skin, identifying diverse cell populations and uncovering complex interactions essential for skin structure, signaling, and function.

This study observed that thymosin beta 4 and VEGF have similar expression patterns in various human tissues, suggesting a role in angiogenesis and organ function.

In this study, targeted inactivation of the integrin-linked kinase gene in melanoblasts led to defects in cell migration, proliferation, and ability to populate the skin, implicating an integrin-linked kinase-Rac1 connection in melanocyte function.

In this review, biomaterial-based mechanical strategies were highlighted for their potential to enhance skin regeneration and promote scarless repair, though a comprehensive understanding of their underlying mechanisms is still needed for broader application.