Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review highlights that current in vitro models often fail to replicate the physiological oxygen levels experienced by different skin cell types, which could affect redox states and functions, potentially accelerating skin aging.

This review addresses the role of skin-resident adult stem/progenitor cells in skin homeostasis, disease, and cancer development, and reports no new research results.

This study identified specific genes upregulated in skin γδ T cells involved in alopecia areata, with findings suggesting these cells contribute to disease pathogenesis through inflammatory and Th1 response mechanisms in mouse and possibly human skin.

This study investigated key genes associated with hair follicle cycle regulation and environmental adaptation in Xinjiang goats, highlighting ELOVL3's role in promoting dermal papilla cell proliferation under varying climates, potentially aiding in cashmere quality improvement and stress-resistant breeding.

This review discusses the mechanisms of skin-associated cell death and their potential role in treating inflammatory skin diseases, but presents no new clinical findings.

This study found that α-melanocyte-stimulating hormone may modulate inflammation in skin connective tissue by inhibiting proinflammatory effects in fibroblasts.

This study found that applying ferrous ferric chloride skin lotions to newborn mice stimulated skin cell proliferation and differentiation, increased hair growth, and inhibited alopecia-related hair loss.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This study found that JunB, a transcription factor, is crucial for maintaining epidermal-pilosebaceous stem cell homeostasis by regulating progenitor cell behavior and preventing sebaceous gland dysfunction.

This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.

This study found that selectively inactivating ribonucleotide excision repair in mouse epidermis leads to DNA damage, keratinocyte intraepithelial neoplasia, and squamous cell carcinoma, indicating a potential tumor-promoting mechanism related to compromised genome maintenance.

This study found that selective inactivation of ribonucleotide excision repair in mouse epidermis led to spontaneous DNA damage, skin inflammation, and the development of squamous cell carcinoma, suggesting potential implications for cancer development in humans.

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

This study suggests that ferrous ferric chloride plays a role in regulating skin homeostasis by promoting the proliferation and differentiation of skin cells from a distance.

This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.

In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.

In this study, researchers found that selectively disabling ribonucleotide excision repair in mouse epidermis caused DNA damage, skin inflammation, and led to skin cancer, suggesting a potential role for this repair mechanism in tumorigenesis.

In this study, exosome-like nanoparticles derived from rose stem cell culture were found to enhance skin quality by increasing collagen production, reducing melanin and inflammation, and promoting cell migration in vitro, suggesting potential aesthetic applications.

In this study with mice, simultaneous inactivation of Smad4 and PTEN genes led to rapid development of invasive forestomach squamous cell carcinomas, mirroring human esophageal SCCs.

In this study, the deletion of Smad4 and PTEN genes in mice was associated with rapid and invasive squamous cell carcinoma formation in the forestomach, modeling human esophageal cancer progression.

This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.

In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.

This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.

Dark skin has stronger barriers and structure due to specific gene activity.

The authors concluded that burned skin contains viable mesenchymal stem cells which enhance wound healing in animal models without altering key biological functions due to burn trauma.

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.