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    Glossary Skin Cell Differentiation

    process where skin stem cells become specialized functional cells

    Skin cell differentiation is the process by which unspecialized cells in the skin, known as stem cells, develop into specialized cells with specific functions, such as keratinocytes, melanocytes, or fibroblasts. This process is crucial for maintaining healthy skin, enabling it to perform various roles like protection, pigmentation, and wound healing.

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    1. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i> bioRxiv (Cold Spring Harbor Laboratory) · 2026
    2. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    3. CLK1 and its Effects on Skin Stem Cell Differentiation Digital WPI · 2010 · 1 citations
    4. 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study Brazilian Journal of Medical and Biological Research · 2025 · 2 citations
    5. Abstract C4: Sp2: A regulator of stem cell differentiation and tumorigenesis Cancer Research · 2009
    6. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    7. The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells International Journal of Molecular Sciences · 2020 · 3 citations
    8. Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma Clinical and Experimental Dermatology · 2019 · 45 citations
    9. Stem Cell-Derived and Plant-Derived Exosomes: Promising Therapeutics for Skin Healing and Regeneration Molecular and Cellular Probes · 2026
    10. 169 TEDAR, a skin-specific long non-coding RNA, orchestrates the late epidermal differentiation program in the human epidermis Journal of Investigative Dermatology · 2025
    11. 1347 Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing Journal of Investigative Dermatology · 2023
    12. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    13. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    14. Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages Cells · 2024 · 7 citations
    15. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    16. The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin PLoS ONE · 2025
    17. 0847 The addition of collagen scaffolds to human cell therapy to modify skin identity Journal of Investigative Dermatology · 2025
    18. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression Cell Reports · 2013 · 15 citations
    19. Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22 PLOS Genetics · 2015 · 52 citations
    20. Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells Stem Cell Reviews and Reports · 2021 · 9 citations
    21. Phospholipase C 1 is required for skin stem cell lineage commitment The EMBO Journal · 2003 · 101 citations
    22. A New Horizon in Facial Plastic Surgery: Skin Tissue-Engineering and Stem Cell Therapy—Reality or Dream? The American Journal of Cosmetic Surgery · 2014 · 2 citations
    23. The role of cell–cell and cell–matrix junctional complexes in sebaceous gland homeostasis and differentiation Cell Communication and Signaling · 2024 · 6 citations
    24. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    25. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    26. Fatty acid oxidation fuels mitochondrial respiration to drive epidermal stem cell fate and differentiation Nature Communications · 2026
    27. 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation 2022
    28. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    29. Retinoic acids shift skin stem cell fate Journal of Investigative Dermatology · 2026
    30. Applications of Human Pluripotent Stem Cell–Derived Skin Organoids in Dermatology 2023 · 1 citations