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    Glossary Skin Barrier

    outermost skin layer protecting against pathogens and moisture loss

    The skin barrier, also known as the epidermal barrier or cutaneous barrier, is the outermost layer of the skin that serves as a protective shield. It prevents the entry of harmful substances, pathogens, and excessive water loss, while also maintaining hydration and overall skin health. This barrier is primarily composed of lipids, proteins, and dead skin cells, and its integrity is crucial for preventing conditions like eczema and infections.

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    Research 30 of 1000+

    1. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    2. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    3. Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions Biological Chemistry · 2008 · 84 citations
    4. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007 · 67 citations
    5. Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing Frontiers in Pharmacology · 2024 · 48 citations
    6. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    7. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology British Journal of Dermatology · 2012 · 33 citations
    8. Caffeine improves barrier function in male skin International Journal of Cosmetic Science · 2006 · 33 citations
    9. Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation Scientific Reports · 2017 · 27 citations
    10. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011 · 22 citations
    11. Skin-associated adipocytes in skin barrier immunity: A mini-review Frontiers in Immunology · 2023 · 20 citations
    12. Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches Medical Science Monitor · 2024 · 18 citations
    13. Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root Molecules · 2023 · 17 citations
    14. Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction International Journal of Molecular Sciences · 2015 · 16 citations
    15. Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis Journal of Investigative Dermatology · 2020 · 15 citations
    16. Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model Food and chemical toxicology · 2017 · 12 citations
    17. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    18. Hair follicles modulate skin barrier function Cell Reports · 2024 · 9 citations
    19. Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin Frontiers in Medicine · 2024 · 8 citations
    20. The Role of PGC-1α in Aging Skin Barrier Function Cells · 2024 · 8 citations
    21. Changes of the skin barrier and bacterial colonization after hair removal by clipper and by razor Journal of Biomedical Photonics & Engineering · 2016 · 6 citations
    22. Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation Frontiers in Immunology · 2025 · 5 citations
    23. Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study JID Innovations · 2024 · 2 citations
    24. Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling Molecules · 2023 · 2 citations
    25. Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model Barrier Immunity · 2025 · 1 citations
    26. Influences of skin barrier, a nanoparticle-based vehicle and solvents on cutaneous drug delivery Refubium (Universitätsbibliothek der Freien Universität Berlin) · 2020 · 1 citations
    27. Research Progress of Skin Barrier and Acne International Journal of Health and Pharmaceutical Medicine · 2023 · 1 citations
    28. 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响(The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne) 中医药研究与应用(Research and application of traditional Chinese medicine) · 2025
    29. 53003 HARNESSING BIOTECHNOLOGICALLY DERIVED ACTIVES FOR SKIN BARRIER RESTORATION IN COMPROMISED SKIN PATIENTS Journal of the American Academy of Dermatology · 2024
    30. Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide Veterinary Dermatology · 2024