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    Glossary Skin Barrier

    outermost skin layer protecting against pathogens and moisture loss

    The skin barrier, also known as the epidermal barrier or cutaneous barrier, is the outermost layer of the skin that serves as a protective shield. It prevents the entry of harmful substances, pathogens, and excessive water loss, while also maintaining hydration and overall skin health. This barrier is primarily composed of lipids, proteins, and dead skin cells, and its integrity is crucial for preventing conditions like eczema and infections.

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    Research 30 of 1000+

    1. Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model Food and chemical toxicology · 2017 · 12 citations
    2. Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide Veterinary Dermatology · 2024
    3. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    4. Caffeine improves barrier function in male skin International Journal of Cosmetic Science · 2006 · 33 citations
    5. Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation Scientific Reports · 2017 · 27 citations
    6. Changes of the skin barrier and bacterial colonization after hair removal by clipper and by razor Journal of Biomedical Photonics & Engineering · 2016 · 6 citations
    7. Research Progress of Skin Barrier and Acne International Journal of Health and Pharmaceutical Medicine · 2023 · 1 citations
    8. Dietary sodium hyaluronate and eggshell membrane improve skin barrier function and coat health in Ragdoll cats Frontiers in Veterinary Science · 2026
    9. 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响(The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne) 中医药研究与应用(Research and application of traditional Chinese medicine) · 2025
    10. 53003 HARNESSING BIOTECHNOLOGICALLY DERIVED ACTIVES FOR SKIN BARRIER RESTORATION IN COMPROMISED SKIN PATIENTS Journal of the American Academy of Dermatology · 2024
    11. Adipose tissue remodeling via TSLP-mediated IL-4/IL-13 signaling: Implications for atopic dermatitis and skin barrier Journal of Allergy and Clinical Immunology · 2024
    12. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    13. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007 · 67 citations
    14. Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction International Journal of Molecular Sciences · 2015 · 16 citations
    15. Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation Frontiers in Immunology · 2025 · 5 citations
    16. Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review Health science reports · 2023
    17. The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss Scientific Reports · 2017 · 19 citations
    18. Does dry skin indicate defective epidermal permeability barrier? Chinese Journal of Dermatology · 2022
    19. Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis Journal of Dermatological Science · 2016 · 1 citations
    20. Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2007
    21. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    22. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    23. Effects of dietary camelina, flaxseed, and canola oil supplementation on inflammatory and oxidative markers, transepidermal water loss, and coat quality in healthy adult dogs Frontiers in Veterinary Science · 2023 · 7 citations
    24. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    25. The role of PPAR<i>γ</i>-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology Experimental Dermatology · 2015 · 84 citations
    26. Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects Skin Pharmacology and Physiology · 2013 · 40 citations
    27. Acyl-CoA binding protein and epidermal barrier function Biochimica and biophysica acta. Molecular and cell biology of lipids · 2014 · 15 citations
    28. Male skin and ingredients relevant to male skin care 2012 · 15 citations
    29. Evaluation of a topical treatment for the relief of sensitive skin Clinical Cosmetic and Investigational Dermatology · 2015 · 9 citations
    30. Induction of autophagy improves skin and hair conditions in dogs with underlying diseases Frontiers in veterinary science · 2023 · 1 citations