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Glossary Skin Barrier Function

protects against external threats and prevents water loss

The Skin Barrier Function, also known as the Epidermal Barrier Function, refers to the skin's ability to protect the body from external threats like pathogens, chemicals, and physical injuries, while also preventing excessive water loss. This function is primarily carried out by the outermost layer of the skin, the stratum corneum, which consists of tightly packed dead skin cells and lipids that form a protective barrier.

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research Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

84 citations , May 2008 in “Biological Chemistry”

This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.

research Hair follicles modulate skin barrier function

9 citations , June 2024 in “Cell Reports”

This study found that hair follicles play a significant role in regulating skin barrier function, with disruptions in the upper hair follicle affecting the epidermis, influencing processes like desquamation and sebum release, and leading to cell movement into the epidermis.

research Dietary sodium hyaluronate and eggshell membrane improve skin barrier function and coat health in Ragdoll cats

July 2026 in “Frontiers in Veterinary Science”

This study found that combined dietary supplementation of sodium hyaluronate and eggshell membrane was associated with various improvements in skin and coat health markers in healthy Ragdoll cats.

research TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function

22 citations , September 2011 in “Journal of Investigative Dermatology”

This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations , August 2021 in “International journal of molecular sciences”

This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.

research The Role of PGC-1α in Aging Skin Barrier Function

8 citations , July 2024 in “Cells”

In this review, researchers explored how PGC-1α might improve aged skin barrier function by influencing mitochondrial function and reducing inflammation, factors that are linked to epidermal health during aging.

research Caffeine improves barrier function in male skin

33 citations , September 2006 in “International Journal of Cosmetic Science”

This study found that applying caffeine significantly improved the skin barrier function of male volunteers by reducing transepidermal water loss compared to female volunteers.

research 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响（The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne）

January 2025 in “中医药研究与应用（Research and application of traditional Chinese medicine）”

In this study involving acne patients, researchers compared the effects of combined fire needle and salicylic acid therapy with conventional treatment, measuring improvements in skin lesion severity, skin barrier function, and microbiota diversity; results are not reported in the abstract.

research 371 Hair follicles are critical modulators of skin barrier function

July 2024 in “Journal of Investigative Dermatology”

Hair follicles are crucial for maintaining skin barrier function.

research Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin

8 citations , December 2024 in “Frontiers in Medicine”

In this study, different treatments on ex vivo skin models effectively simulated varying levels of skin damage, demonstrating the value of these models in testing skin repair products and studying how a compromised skin barrier affects viral penetration.

research The role of tight junctions in skin barrier function and dermal absorption

156 citations , August 2016 in “Journal of controlled release”

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

Considering the Risk of Coloring Shampoo for Gray Hair Cover in Cosmetology and Skin Barrier: A Systematic Review

research Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review

May 2023 in “Health science reports”

This review discusses the harmful effects of coloring shampoos containing trihydroxybenzene on the scalp-skin barrier and emphasizes the need for safer ingredient selection to prevent side effects.

research Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling

2 citations , August 2023 in “Molecules”

This study found that a quinazoline derivative, SH-340, increased skin barrier-associated factors and inhibited TSLP expression and STAT6 phosphorylation in human primary keratinocytes, suggesting potential benefits for alleviating inflammation and improving skin barrier function in atopic dermatitis.

research 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions

April 2017 in “Journal of Investigative Dermatology”

Applying pseudoceramide improved skin and hair health.

research The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function)

August 2015 in “Free Radical Biology and Medicine”

This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.

research 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function

September 2017 in “Journal of Investigative Dermatology”

This study suggests that activating the hexosamine pathway may enhance skin homeostasis, potentially increasing hair follicle stem cells and modifying extracellular matrix components like hyaluronic acid in vitro.

research Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function

11 citations , August 2022 in “Journal of Investigative Dermatology”

research Research Progress of Skin Barrier and Acne

1 citations , March 2023 in “International Journal of Health and Pharmaceutical Medicine”

This review summarizes the link between acne pathogenesis and skin barrier dysfunction, noting that more severe acne correlates with greater skin barrier damage, but reports no new clinical results.

research Expression and Function of Group IIE Phospholipase A2 in Mouse Skin

26 citations , May 2016 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that mice lacking sPLA2-IIE had distinct skin abnormalities, particularly affecting hair follicles, highlighting the differing roles of sPLA2 isoforms in mouse skin.

research The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss

19 citations , March 2017 in “Scientific Reports”

This study suggests that the protease HAT-L4 plays a significant role in maintaining epidermal barrier function to prevent body fluid loss, as its absence in mice led to increased fluid loss and higher mortality.

research Acyl-CoA binding protein and epidermal barrier function

15 citations , March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

This review discusses the role of acyl-CoA binding protein (ACBP) in the epidermal barrier, noting that its disruption in mice is linked to skin and fur abnormalities; it reports no new clinical results.

research Adipose tissue remodeling via TSLP-mediated IL-4/IL-13 signaling: Implications for atopic dermatitis and skin barrier

June 2024 in “Journal of Allergy and Clinical Immunology”

In this study, thymic stromal lymphopoietin (TSLP) induced IL-4/IL-13 from T cells, prompting sebum secretion and adipose loss, suggesting IL-4/IL-13 may affect skin barrier function in atopic dermatitis.

research The Endocrine Function of the Skin: An Analytical Narrative

October 2023 in “Apollo medicine”

This review highlights that the epidermis acts as an endocrine organ, synthesizing and responding to hormones such as corticosteroids and Vitamin D, impacting processes like hair growth and immune response, and participating in regulating endocrine balance.

research The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function

1 citations , January 2013

This study observed that inducible deletion of the Ugcg gene in mouse epidermis led to a significant reduction in GlcCers and epidermal POS-Cers, causing impaired skin barrier function and delayed wound healing.

research Citrullination at the Inflammatory Skin Barrier

May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that baricitinib can counteract the cytokine-driven reduction of the enzyme PADI1 in human keratinocytes, which may help improve skin barrier function in atopic dermatitis by enabling epidermal differentiation.

research The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis

January 2014 in “eScholarship (California Digital Library)”

In this study, researchers observed that TLR3 and scavenger receptors play key roles in skin barrier repair following UVB damage, contributing to our understanding of cellular responses to skin injury.

Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.

research Structure and Function of the Skin

6 citations , January 2009 in “Elsevier eBooks”

This chapter discusses the structure and function of the skin, detailing its protective roles and the layers that comprise it, but reports no new research findings.

research 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin

November 2025 in “Journal of Investigative Dermatology”

Dark skin has stronger barriers and structure due to specific gene activity.

research Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia

52 citations , December 2000 in “Archives of Dermatological Research”

This study found that the stratum corneum of scalp skin in humans has distinct functional characteristics compared to the facial skin and volar forearm, including higher hydration levels and intermediate epidermal turnover rates.