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    Glossary Skin Barrier Function

    protects against external threats and prevents water loss

    The Skin Barrier Function, also known as the Epidermal Barrier Function, refers to the skin's ability to protect the body from external threats like pathogens, chemicals, and physical injuries, while also preventing excessive water loss. This function is primarily carried out by the outermost layer of the skin, the stratum corneum, which consists of tightly packed dead skin cells and lipids that form a protective barrier.

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    Research 30 of 1000+

    1. Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions Biological Chemistry · 2008 · 84 citations
    2. Hair follicles modulate skin barrier function Cell Reports · 2024 · 9 citations
    3. Dietary sodium hyaluronate and eggshell membrane improve skin barrier function and coat health in Ragdoll cats Frontiers in Veterinary Science · 2026
    4. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011 · 22 citations
    5. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    6. The Role of PGC-1α in Aging Skin Barrier Function Cells · 2024 · 8 citations
    7. Caffeine improves barrier function in male skin International Journal of Cosmetic Science · 2006 · 33 citations
    8. 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响(The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne) 中医药研究与应用(Research and application of traditional Chinese medicine) · 2025
    9. 371 Hair follicles are critical modulators of skin barrier function Journal of Investigative Dermatology · 2024
    10. Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin Frontiers in Medicine · 2024 · 8 citations
    11. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    12. Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review Health science reports · 2023
    13. Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling Molecules · 2023 · 2 citations
    14. 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions Journal of Investigative Dermatology · 2017
    15. The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) Free Radical Biology and Medicine · 2015
    16. 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function Journal of Investigative Dermatology · 2017
    17. Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function Journal of Investigative Dermatology · 2022 · 11 citations
    18. Research Progress of Skin Barrier and Acne International Journal of Health and Pharmaceutical Medicine · 2023 · 1 citations
    19. Expression and Function of Group IIE Phospholipase A2 in Mouse Skin 2016 · 26 citations
    20. The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss Scientific Reports · 2017 · 19 citations
    21. Adipose tissue remodeling via TSLP-mediated IL-4/IL-13 signaling: Implications for atopic dermatitis and skin barrier Journal of Allergy and Clinical Immunology · 2024
    22. The Endocrine Function of the Skin: An Analytical Narrative Apollo medicine · 2023
    23. Acyl-CoA binding protein and epidermal barrier function Biochimica and biophysica acta. Molecular and cell biology of lipids · 2014 · 15 citations
    24. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    25. Citrullination at the Inflammatory Skin Barrier 2023
    26. The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis eScholarship (California Digital Library) · 2014
    27. Structure and Function of the Skin Elsevier eBooks · 2009 · 6 citations
    28. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    29. 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin Journal of Investigative Dermatology · 2025
    30. Skin: Basic Structure and Function Elsevier eBooks · 2014 · 36 citations