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Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.

Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

The skin microbiome helps heal wounds and can be targeted to improve healing.

Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.

Certain gene mutations can weaken the skin barrier and, when combined with environmental factors, lead to eczema and severe itching.

ACBP is crucial for healthy skin in mice.

Unconventional lymphocytes are important for quick immune responses and healing of skin and mucosal barriers.

Notch signaling disruptions can cause various skin diseases.

Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.

Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Environmental factors can cause mutations in skin proteins, leading to skin disorders.

STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

Removing the Crif1 gene in mouse skin disrupts skin balance and hair growth.

Nanoparticles improve minoxidil skin permeation, but more research needed for effective hair growth.

New physical methods like electrical currents, ultrasound, and microneedles show promise for improving drug delivery through the skin.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

Thermoresponsive nanogels show promise for delivering medicine through the skin but need more safety testing and regulatory approval before clinical use.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

SCD1 is crucial for skin health and overall energy balance.