40 citations
,
November 2021 in “International Journal of Molecular Sciences” This review highlights the role of keratin mutations in epidermolysis bullosa simplex and the resulting chronic inflammation, but it presents no new experimental findings.
32 citations
,
July 2017 in “Molecular diagnosis & therapy” MicroRNA-21 could help diagnose and treat skin fibrosis.
27 citations
,
October 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of histone marks in the transition between quiescence and proliferation in cells, and reports no new findings, emphasizing the potential existence of a histone "code" for quiescence.
19 citations
,
January 2023 in “Frontiers in Bioengineering and Biotechnology” This review discusses the therapeutic potential of mesenchymal stem cell-derived small extracellular vesicles for chronic wound treatment and reports no new clinical results, emphasizing the need for further research on their large-scale production and engineering.
18 citations
,
March 2015 in “Journal of Investigative Dermatology” In this study, silencing BMAL1 and PER1 genes increased melanogenic activity in follicular and epidermal melanocytes, suggesting that peripheral circadian clocks may regulate melanin pigmentation.
9 citations
,
November 2021 in “Frontiers in Cell and Developmental Biology” This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by alleviating ROS-mediated DNA damage, rather than enhancing DNA repair.
6 citations
,
May 2022 in “Frontiers in Microbiology” This review evaluates the potential of natural products from marine microorganisms for cosmetic applications and reports no new experimental results, highlighting challenges and prospects in their use.
4 citations
,
September 2025 in “Biomolecules” This narrative review discusses the mixed and evolving evidence regarding glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and their influence on erectile dysfunction in men with type 2 diabetes and obesity, highlighting potential benefits and concerns yet to be clarified.
4 citations
,
August 2025 in “Journal of Food Science” This review highlights that Tremella fuciformis polysaccharide exhibits various bioactivities, such as antioxidant and immune-modulating effects, and explores its potential applications in food, pharmaceutical, and cosmetic industries.
3 citations
,
May 2022 in “Experimental Dermatology” This review discusses the role of hair follicle stem cell metabolism, ageing, and microenvironment in hair growth disorders and compiles recent research on using stem cell-based regenerative medicine for treating alopecia, without reporting new clinical results.
2 citations
,
December 2025 in “Annals of Medicine” This review discusses the complex correlation between cellular senescence and PCOS, emphasizing senescence markers, mechanisms, and potential anti-senescence therapies, but reports no new clinical results.
2 citations
,
April 2025 in “Plants” This study found that lambertianic acid from Platycladus orientalis leaves may protect against dexamethasone-induced skeletal muscle atrophy by reducing atrophy-related proteins without affecting cell viability.
2 citations
,
February 2021 in “Developmental Cell” This study reports that aging in human skin involves early photo- and inflammation-related cellular changes, and suggests restoring KLF6 and HES1 expression might reverse some of these age-associated changes.
1 citations
,
November 2025 in “Aging Cell” This review discusses the role of the ectodysplasin A2 receptor as a biomarker and driver of ageing related to inflammation, and its potential therapeutic implications, but reports no new clinical findings.
1 citations
,
February 2023 in “Ibrain” This review discusses the neuroprotective properties of Nigella sativa and its nanoformulations for treating neurodegenerative disorders, without presenting new clinical results.
April 2026 in “The Open Biotechnology Journal” This review reports that resveratrol could benefit the management of chronic illnesses such as diabetes and cardiovascular disease, but challenges with bioavailability and regulatory issues persist.
July 2025 in “Preprints.org” This study observed distinct plasma miRNA profiles in alopecia areata, identifying several miRNAs downregulated in both mild and severe forms; machine learning models demonstrated strong predictive accuracy, and kinase inhibitors were suggested as promising therapeutic targets based on pathway analysis.
April 2024 in “Biomolecules” This review summarizes recent findings on the role of mesenchymal stem cell-derived exosomal microRNAs in skin regeneration and rejuvenation, discussing their potential for treating skin damage and aging, and exploring bioengineering methods to enhance therapeutic effects.
November 2023 in “British journal of nutrition” This study found that curcumin supplementation in adults significantly increased serum adiponectin levels and decreased leptin levels, based on a meta-analysis of 13 randomized controlled trials.
November 2025 in “Journal of Nanobiotechnology” This study found that in androgenetic alopecia mice, MNX@Arg-CLAVs, a novel nanovesicle platform containing minoxidil and conjugated linoleic acid, enhanced hair regeneration and reduced hair follicle aging more effectively and with less irritation compared to traditional minoxidil tincture.
95 citations
,
August 2013 in “Journal of Investigative Dermatology” HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.
65 citations
,
November 2013 in “The EMBO Journal” HDAC1 is crucial for skin development and preventing tumors.
13 citations
,
May 2024 in “Frontiers in Aging” This article reviews how stem cell exhaustion contributes to aging, emphasizing the balance between proliferation and quiescence as crucial for long-term stem cell maintenance, but it reports no new results.
November 2025 in “Journal of Clinical Medicine” This narrative review highlights innovations in regenerative medicine and longevity research within plastic surgery, emphasizing biological, ethical, and regulatory aspects. The study underscores the potential to extend healthspans while balancing these advances with ethical considerations and safety.
October 2025 in “Phytomedicine” This study demonstrates that Bazi Bushen capsules may have therapeutic potential against skin photoaging in mice by enhancing NRF2 expression and targeting the KEAP1-NRF2 pathway.
November 2020 in “IntechOpen eBooks” This review discusses the role of mineral nutrients in human health, emphasizing the importance of dietary sources and education to prevent mineral deficiencies, and reports no new clinical results.
August 2015 in “Free Radical Biology and Medicine” This study explores the correlation between sirtuins' expression, histone deacetylation, and redox status in young and old monozygotic twins to understand their role in age-related mechanisms.
July 2025 in “Journal of Investigative Dermatology”
August 2015 in “Free Radical Biology and Medicine” Some treatments can improve skin's defense against damage, but overuse may cause other skin problems.
This study found that periodic red light exposure increased histone acetylation and activated metabolic processes in aged mice, leading to enhanced fatty acid oxidation and the mitigation of cellular aging by influencing gene expression and metabolic regulation.