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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

New effective scar treatments are urgently needed due to the current options' limited success.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

Certain genes control the color of human hair by affecting pigment production.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

The hair follicle is a great model for research to improve hair growth treatments.

Lamins are vital for cell survival, organ development, and preventing premature aging.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

Improving the environment and cell interactions is key for creating human hair in the lab.

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

Polyamines help fix DNA damage accurately in cells.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Autophagy is important for human hair growth and health.

Low-dose UVB light improves hair growth effects of certain stem cells by increasing reactive oxygen species.