1 citations,
April 2023 in “Science Advances” High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.
February 2024 in “International Journal of Molecular Sciences” Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
9 citations,
February 2021 in “Frontiers in Cell and Developmental Biology” Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.
8 citations,
June 2022 in “Scientific Reports” LGR5 is a common marker of hair follicle stem cells in different animals and is important for hair growth and regeneration.
7 citations,
June 2022 in “Frontiers in Medicine” ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.
7 citations,
February 2022 in “Stem cell reviews and reports” Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.
7 citations,
June 2020 in “npj regenerative medicine” GDNF helps grow hair and heal skin wounds by acting on hair stem cells.
5 citations,
March 2022 in “Stem cell reports” Thymic stromal lymphopoietin (TSLP) promotes hair growth, especially after skin injury.
2 citations,
September 2023 in “International journal of molecular sciences” Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
August 2024 in “Cell Death and Disease” Activating TLR9 helps heal wounds and regrow hair by using specific immune cells.
53 citations,
May 2021 in “Cell Host & Microbe” Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.
4 citations,
October 2021 in “Journal of Cellular and Molecular Medicine” White blood cells and their traps can slow down the process of new hair growth after a wound.
1 citations,
June 2023 in “Animals” CRABP2 helps increase the growth of cells important for hair growth by activating a specific growth pathway.
May 2023 in “Frontiers in Cell and Developmental Biology” The document concludes that using stem cells to regenerate hair follicles could be a promising treatment for hair loss, but there are still challenges to overcome before it can be used clinically.
2 citations,
September 2022 in “Frontiers in Immunology” T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
1 citations,
December 2022 in “Frontiers in Immunology” Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.
January 2024 in “Journal of developmental biology” Abdominal skin heals faster than dorsal skin because it has more stem cells.
8 citations,
July 2020 in “BMC genomics” The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
15 citations,
December 2020 in “International journal of molecular sciences” Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.
9 citations,
July 2022 in “Cell reports” Sox2 controls hair color by affecting pigment production in hair follicles.
28 citations,
October 2019 in “Seminars in Cell & Developmental Biology” Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.
10 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
20 citations,
November 2021 in “Frontiers in cell and developmental biology” Skin organoids from stem cells could better mimic real skin but face challenges.
July 2020 in “Journal of Investigative Dermatology” Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.
24 citations,
December 2019 in “Experimental cell research” BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.
5 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Fat tissue under the skin affects hair growth and aging; reducing its inflammation may help treat hair loss.
September 2023 in “Nature communications” Alk1 in specific cells is crucial for proper nerve branching and hair function.
10 citations,
March 2022 in “Communications biology” A new non-invasive method can analyze skin mRNA to understand skin diseases better.
9 citations,
May 2021 in “Immunological Reviews” Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.