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The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.

New treatments targeting specific genes show promise for treating keratin disorders.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Minoxidil and finasteride effectively treat hair loss.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

EDA2R gene linked to hair loss.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

The document concludes that alopecia areata is an autoimmune disease without a definitive cure, but treatments like corticosteroids are commonly used.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

Scientists found a gene in mice that causes early hearing loss.