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This study found that castration increased 5 alpha-reductase activity in the sebaceous glands of male hamsters, but administering testosterone propionate or 5 alpha-dihydrotestosterone inhibited this effect.

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

In this rat study, finasteride treatment significantly reduced body, testis, epididymis, and prostate weights and affected testicular histology, indicating potential negative impacts on testicular function.

This study found that exposure to finasteride impaired spermatogenesis in male Xenopus laevis by affecting sex-specific feedback mechanisms in the hypothalamus–pituitary–gonad axis.

This study found that paternal exposure to finasteride in male rats may impair fertility and affect androgen-sensitive spermatogenesis in their male offspring.

Finasteride may cause weak ejaculation and reduced semen volume.

Researchers observed that dutasteride and finasteride caused structural changes in the penises of both control and hypertensive rats, with dutasteride having a more pronounced effect on the corpus cavernosum.

In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.

This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.

This case report describes a rare instance of multiple sebaceous cysts over the scrotum in a 22-year-old man, highlighting the effectiveness of ultrasound imaging for diagnosis and the need for surgical intervention in severe cases.

In this study, Scutellaria baicalensis was observed to reduce tissue damage and inhibit 5α-reductase expression in a rat model of benign prostatic hyperplasia.

This study found that finasteride administration in hamsters led to significant spermatogenesis reduction and seminiferous tubule atrophy compared to the control group.

This study found that dual 5α-reductase inhibitors in rats decreased sperm quality and led to reduced pregnancy success, suggesting potential for use in male contraception.

The study observed that finasteride reduced fertility in male Sprague-Dawley rats by impairing the formation of copulatory plugs, an effect considered specific to rats and not applicable to species without this reproductive feature.

This study found that chronic administration of finasteride in rats led to significant alterations in the epididymis and compromised sperm quality, effects that persisted even after 30 days of treatment cessation.

This study found that adolescent men in Ireland are more likely to prefer keeping a baby over abortion in a hypothetical unplanned pregnancy, influenced by their anticipated regret and perceived familial attitudes.

This case report highlights the importance of considering pituitary stalk interruption syndrome as a potential diagnosis for patients with short stature, as early detection may allow those affected to achieve normal height.

This case report describes the successful surgical treatment of seminoma in an 8-year-old German Shepherd with a distended abdomen and urinary incontinence.

This study found that young men using finasteride for androgenic alopecia exhibited erectile tissue fibrosis and associated sexual dysfunction, including low libido and mood changes.

This study found that transdermal DHT treatment increased penile length in boys with 5α-reductase type 2 deficiency, but post-pubertal growth was limited and carried potential prostate complications.

In this study, treatment with finasteride altered the expression patterns of antioxidant enzymes in the epididymis of rats, potentially affecting its protective function for spermatozoa.

This study found that micro-CT imaging can effectively identify vascular structures in rat models of congenital hypospadias, providing anatomical insights for selecting preputial vessel flaps in surgical procedures.

In this study, testosterone and finasteride were found to increase insulin and zinc levels while decreasing chromium levels in male adult rats, suggesting potential effects on the glucose cycle.

This study found that male pattern baldness and a history of severe acne were inversely associated with testicular germ cell tumors, while taller height showed a positive association.

This case report describes an extremely rare instance of seminoma in an adult with SRY-negative 46,XX testicular disorder of sex development, uniquely presenting as acute abdomen due to gonadal torsion.

This study investigated the effects of 5-alpha-reductase inhibitors on penile histomorphometry in both normotensive and hypertensive rats, reporting no significant changes between treated and untreated groups.

This study observed that circulating testosterone affects baseline sex differences in voiding function in C57BL/6J mice, with prostate lobe mass having a lesser impact.