202 citations,
August 2017 in “Nature cell biology” Lactate production is important for activating hair growth stem cells.
74 citations,
January 2013 in “Expert Opinion on Biological Therapy” The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.
51 citations,
November 2013 in “Drug Discovery Today” Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
42 citations,
July 2014 in “Journal of biological chemistry/The Journal of biological chemistry” Heparan sulfate is important for hair growth, preventing new hair formation in mature skin, and controlling oil gland development.
38 citations,
June 2019 in “International Journal of Molecular Sciences” Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.
31 citations,
May 2008 in “Drug Discovery Today: Disease Mechanisms” Different hair growth problems are caused by genetic issues or changes in hair growth cycles, and new treatments are being developed.
30 citations,
December 2018 in “Trends in Endocrinology and Metabolism” Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.
237 citations,
June 2013 in “Nature Medicine” A protein from certain immune cells is key for new hair growth after skin injury in mice.
182 citations,
August 2016 in “Development” ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.
158 citations,
August 2011 in “Reviews in endocrine and metabolic disorders” Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
129 citations,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
57 citations,
March 2013 in “Journal of Dermatological Science” Improving the environment and cell interactions is key for creating human hair in the lab.
32 citations,
July 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.
23 citations,
February 2020 in “PLOS genetics” Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.
18 citations,
December 2009 in “Canadian Journal of Animal Science” The BMP2 gene is more active in the early growth phase of Cashmere goat hair and may affect hair regeneration and textile production.
17 citations,
December 2019 in “Stem Cells International” Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
17 citations,
February 2019 in “PubMed” Stem cells can help regenerate hair follicles.
13 citations,
July 2022 in “Frontiers in cell and developmental biology” Tiny natural vesicles from cells might help treat hair loss.
9 citations,
June 2020 in “Tissue Engineering and Regenerative Medicine” HHORSC exosomes and PL improve hair growth treatment outcomes.
9 citations,
March 2013 in “Expert opinion on biological therapy” Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.
6 citations,
May 2013 in “PloS one” The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.
2 citations,
January 2023 in “International journal of biological sciences” Gray hair can potentially be reversed, leading to new treatments.
1 citations,
June 2010 in “Development” The document concludes that pig iPSCs show promise for transplant therapies and the field is advancing in controlling cell behavior for biology and medicine.
February 2024 in “Frontiers in physiology” Hair follicle stem cells help skin heal and grow during stretching.
December 2023 in “Communications biology” Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.
November 2023 in “Frontiers in veterinary science” The study provides insights into hair growth mechanisms in yaks.
July 2022 in “Research Square (Research Square)” Certain miRNAs may play a role in sheep hair follicle development, which could help improve wool production.
November 2021 in “Austin therapeutics” Current treatments for hair loss from chemotherapy are limited, but new methods are being researched.
Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.
January 2018 in “Stem cell biology and regenerative medicine” ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.