January 2008 in “Journal of Clinical Dermatology” This study found that integrin alpha-6 and p63 may play a role in hair loss, with variable expression patterns in different types of alopecia observed in scalp biopsy samples.
September 2017 in “Journal of Investigative Dermatology” This study found that intradermal injections of cultured autologous dermal sheath cup cells for androgenetic alopecia showed hair loss stabilization at 24 months without serious adverse effects and a sustained response in some participants.
92 citations
,
June 2005 in “Journal of Investigative Dermatology” This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.
2 citations
,
March 2013 in “Hair transplant forum international” This article discusses the concept of hair cloning through cultured follicular cell implantation but provides no new experimental results; it highlights ongoing interest among hair restoration professionals and the public.
January 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that ageing in women leads to significant structural and biological changes in the scalp hair follicle environment, which may affect hair growth.
April 2017 in “Journal of dermatological science” This study found that while epidermal PLCγ1 is not necessary for keratinocyte differentiation in interfollicular epidermis, it is crucial for normal hair and sebaceous gland formation in mice.
January 2022 in “Stem cell biology and regenerative medicine” This review discusses the role of dermal sheath cells in hair follicle regeneration, suggesting they show potential for treating pattern hair loss, but emphasizes the need for further human studies.
This study suggests that targeting the activation of transit-amplifying cell-derived progenitor cells may help prevent hair loss from chemotherapy and radiotherapy by promoting hair follicle regeneration.
31 citations
,
August 2000 in “Journal of Investigative Dermatology” This study found that when human hair follicles were grafted onto mice, they progressed through dystrophic stages and returned to normal growth, with stem cells aiding in recovery.
6 citations
,
July 2012 in “Experimental Dermatology” In this study, treatment with human follicular keratinocyte-conditioned media improved the trichogenicity of cultured dermal cells by activating key signalling pathways, suggesting its potential use in cell therapy for hair loss.
This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.
November 2022 in “Journal of Investigative Dermatology” This study found that a lotion containing specific plant extracts significantly increased the number of anagen hairs and the anagen/telogen ratio in subjects with androgenetic alopecia after three months of use.
56 citations
,
January 2001 in “Dermatology” This study introduces the concept of teloptosis, which influences hair shedding during the telogen phase and affects hair density, highlighting that early or delayed teloptosis has noticeable effects.
25 citations
,
July 2008 in “British Journal of Dermatology” This study observed dynamic changes in CD10 and CD34 expression in fetal and adult human hair follicles during embryogenesis and hair cycling.
8 citations
,
September 2016 in “Journal of the American Academy of Dermatology” It's important to tell the difference between hair casts, pseudocasts, and nits.
1 citations
,
January 2022 in “Stem cell biology and regenerative medicine” This review discusses the potential of cell therapies using dermal papilla and dermal sheath cells for androgenetic alopecia, highlighting their ability to reverse hair follicle miniaturization but not yet achieving significant cosmetic efficacy in trials.
July 2020 in “Experimental Dermatology” This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.
April 2018 in “Journal of Investigative Dermatology” This study reports that in aged mice, hair follicle dermal stem cells exhibit diminished self-renewal and preferential differentiation into dermal sheath cells, contributing to age-related hair loss.
May 2015 in “Hair transplant forum international” This review discusses androgenetic alopecia and reports no clinical findings; the authors highlight a need for further research.
12 citations
,
February 2010 in “Journal of The American Academy of Dermatology” This article discusses the use of cetuximab for recurrent squamous cell skin cancer in palliative care, noting good responses but frequent cutaneous side effects; it presents no new findings.
158 citations
,
May 2003 in “Journal of Investigative Dermatology” This study observed that hair follicle mesenchyme in mice exhibits significant plasticity during the hair cycle, with cell migration and changes in papilla size impacting hair production.
132 citations
,
August 2008 in “Development” This research found that Dlx3 plays a central role in hair formation and regeneration, with its absence leading to alopecia through disrupted differentiation and signaling pathways.
112 citations
,
September 1968 in “PubMed” In this study, irreversible alopecia on the crown of the scalp in Black women using hot combs was associated with chronic inflammation and follicle damage leading to scarring.
107 citations
,
September 1968 in “Archives of Dermatology” In this study, researchers identified a form of irreversible scalp alopecia in Black women using hot combs, characterized by incomplete hair loss primarily on the crown and follicular scarring.
105 citations
,
May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that activation of the TRPV3 ion channel inhibits human hair growth by affecting hair follicles and outer root sheath keratinocytes.
90 citations
,
June 2006 in “The American Journal of Dermatopathology” This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.
88 citations
,
July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
73 citations
,
January 2004 in “Journal of the American Academy of Dermatology” Immunocompromised patients can develop skin and hair issues due to a virus.
67 citations
,
May 2014 in “International Journal of Molecular Sciences” This review outlines the role of dermal fibroblasts in wound healing and highlights their potential in developing new cellular therapies, but reports no new clinical results.
58 citations
,
March 2019 in “Experimental Dermatology” This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.