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Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Progranulin overexpression leads to shorter, thinner hair and increased cell death in mouse hair follicles.

New compounds may soon be tested to treat excessive hair growth in women.

Older men with lower levels of available testosterone are more likely to be frail.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Finasteride exposure harms tadpole reproduction and hormone balance.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Women with acne have lower levels of a specific hormone marker than women without acne.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

Flutamide and finasteride reduced sex hormones in pregnant hyenas, but increased them in males.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.

Hormone treatment before hypospadias surgery can increase penis size and reduce surgery complications.

Phytoconstituents from Cyperus Rotundus may help treat hirsutism by interacting with the 5 α reductase enzyme.