research The Role of Cytochrome P-450 in Dermatology
Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.
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research The Mineralocorticoid Receptor as a Novel Player in Skin Biology: Beyond the Renal Horizon?
The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.
research Mechanisms of Action of Dehydroepiandrosterone
DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.
research Survival of Patchwork Melanoblasts Is Dependent Upon Their Number in the Hair Follicle at the End of Embryogenesis
More melanoblasts in hair follicles mean better survival and proper hair pigmentation.
research Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
research Androgens And Hirsutism In A Large Cohort Of Portuguese Women
PCOS is the most common cause of hirsutism, and personalized treatment is important.
research The Impact of Certain Genetic Variants (Single Nucleotide Polymorphisms) on Incidence and Severity of COVID-19
Certain genetic differences may affect how likely someone is to get COVID-19 and how severe it might be.
research Antioxidants and Mitochondrial Bioenergetics: Charnoly Bodies in Neurodegenerative Diseases, Cardiovascular Disorders, and Cancer
Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.
research 5α-Reductase Inhibitors: Chemical and Clinical Models
Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.
research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia
Androgens, like DHT, affect hair growth and treatments like finasteride may help.
research Seven Aesthetic Facial Proportions
The document concludes that ideal facial proportions are guided by specific measurements and symmetry to enhance beauty, but individual characteristics must be considered.
research The Use of Neurotoxins in the Male Face
Men need higher doses of botox than women and a different approach for facial aesthetics due to their unique facial features and muscle mass.
research Clinical Applications of Antiandrogens
Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.
research Androgens and Hair: A Biological Paradox
Androgens can cause hair growth in some areas but hair loss on the scalp.
research Cutaneous Malignant Melanoma Incidences Analyzed Worldwide by Skin Type Over Advancing Age of Males and Females: Evidence Estrogen and Androgenic Hair Are Risk Factors
Estrogen and androgenic hair increase melanoma risk, especially in European-ancestry individuals.
research Finasteride
research STUB1 Mutations in Autosomal Recessive Ataxias – Evidence for Mutation-Specific Clinical Heterogeneity
Different STUB1 gene mutations cause varied symptoms in autosomal recessive ataxias.
research The Evaluation and Management of Hirsutism
Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.
research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis
PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
research The Current and Emerging Role of Statins in the Treatment of Polycystic Ovary Syndrome: The Evidence to Date
Statins may help treat PCOS by lowering androgen levels and improving cholesterol.
research Effect of 5-Alpha Reductase Inhibitors in Animal Models of Parkinson's Disease
5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.
research Novel Androgen Receptor Gene Variant Containing a Premature Termination Codon in a Patient with Androgen Insensitivity Syndrome
A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.
research Position Effect on FGF13 Associated with X-Linked Congenital Generalized Hypertrichosis
FGF13 gene changes cause excessive hair growth in a rare condition.
research The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver
Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.
research Profiling of Hair Proteome Revealed Individual Demographics
Hair protein analysis might help identify a person's ethnicity, sex, and age in forensics.
research Androgenetic Alopecia: Update on Etiology, Pathophysiology, Diagnosis, and Treatment
Androgenetic alopecia is influenced by various factors and can be treated with medications, procedures, and non-drug methods.
research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism
The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
research Higher PDCD4 Expression Is Associated With Obesity, Insulin Resistance, Lipid Metabolism Disorders, And Granulosa Cell Apoptosis In Polycystic Ovary Syndrome
More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.
research Uncombable Hair Syndrome and Beyond
Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.
research Current Concepts of Polycystic Ovary Syndrome
PCOS is often caused by hormonal imbalances that can lead to various health issues and may indicate a risk for future metabolic and cardiovascular problems.