research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors
Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
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research DHT and E2 Synthesis-Related Proteins and Receptors Expression in Male Yak Skin During Different Hair Follicle Stages
Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.
research Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats
Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
research Sex Hormones and Related Compounds, Including Hormonal Contraceptives
Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.
research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition
The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp
Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia
Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism
The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
research Indirect Clinical Markers for the Detection of Anabolic Steroid Abuse Beyond Conventional Doping Control in Athletes
New signs like changes in blood markers, physical symptoms, and behavioral shifts may help detect hidden steroid use in athletes.
research Hedonic Sensitivity to Natural Rewards Is Affected by Prenatal Stress in a Sex-Dependent Manner
Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.
research The Role of Androgen and Androgen Receptor in Skin-Related Disorders
Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
research Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome
Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.
research Analysis of Androgen Receptor Expression and Activity in the Mouse Brain
Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.
research Effect of Flutamide and Two Novel Synthetic Steroids on GABA, Glutamine, and Some Oxidative Stress Markers in Rat Brain and Prostate
Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.
research Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol
Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.
research Finasteride: The First 5α-Reductase Inhibitor
Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.
research Interaction Between Estrogens and Androgen Receptor Genes Microsatellites, Prostate-Specific Antigen, and Androgen Receptor Expressions in Breast Cancer
Certain gene patterns in breast cancer are linked to how active hormone receptors are and could affect patient survival.
research Coat Condition, Housing Condition, And Measurement Of Fecal Cortisol Metabolites: A Non-Invasive Study About Alopecia In Captive Rhesus Macaques (Macaca Mulatta)
Alopecia in captive rhesus macaques is affected by season, sex, age, housing, and stress, with complex links between stress hormones and hair loss.
research Effect of Non-Steroidal Anti-Inflammatory Drugs on Post-Surgical Complications Against the Backdrop of the Opioid Crisis
NSAIDs may not affect soft tissue healing but should be used carefully for bone fractures and more research is needed to understand sex differences in response.
research Treatment of Hirsutism with the Pure Antiandrogen Flutamide
Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
research Rare Virilizing Tumor: Ovarian Steroid Cell Tumor, Not Otherwise Specified: A Case Report
A 20-year-old woman was found to have a rare ovarian tumor causing symptoms like acne and a low-pitched voice, which disappeared after the tumor was removed.
research Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells
Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.
research Anti-Androgen Treatment of Hirsute Women: A Study on Stress Responses
The treatment reduced hair growth and testosterone in women with excess hair and had some effects on stress responses.
research Androgenetic Alopecia: An Autosomal Dominant Disorder
Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.
research Hair Follicles and Associated Glands as Androgen Targets
Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.
research Activation of Extrasynaptic δ-GABAA Receptors Globally or Within the Posterior VTA Has Estrous-Dependent Effects on Alcohol Consumption and Estrous-Independent Effects on Locomotion
δ-GABAA receptors affect alcohol consumption based on the estrous cycle and influence movement regardless of the cycle.
research Androgens and Hair: A Biological Paradox with Clinical Consequences
Androgens can both increase body hair and cause scalp hair loss.
research Effects of Neonatal and Adolescent Neuroactive Steroid Manipulation on Locomotor Activity Induced by Ethanol in Male Wistar Rats
Changing neuroactive steroid levels early in life can affect how adult rats respond to alcohol's stimulating effects.
research Use of Oral Contraceptives in the Management of Acne
Birth control pills with low-dose estrogen and antiandrogenic progestins can effectively treat acne.