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High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Hormone therapy affects cancer risks in transgender individuals differently than in cisgender people, and more research is needed to understand these risks and improve cancer screening guidelines.

The Pemphigus Disease Area Index and Autoimmune Bullous Skin Disorder Intensity Score are the best tools for assessing pemphigus severity.

Sex hormones might influence bladder cancer development, and aromatase inhibitors could increase risk in postmenopausal women.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Eyelashes are important for looks and eye protection, and more people are treating sparse eyelashes; more research is needed to understand eyelash biology and improve treatments.

New understanding of hair loss could lead to better treatments.

Certain medications can negatively impact male fertility.

Low vitamin D receptor levels found in hair loss patients; topical vitamin D treatment suggested.

Some medications can cause reversible hair loss by affecting hair growth cycles.

No significant link was found between the studied genes and female hair loss in the Polish population.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Healthcare providers need better understanding and cultural sensitivity to improve care for transgender patients with kidney failure needing transplants.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Australian doctors experienced in adult transgender healthcare mostly prescribe intramuscular testosterone and oral estradiol, recommend mental health assessments before hormone therapy, and support improved training and guidelines.

Conditions affecting sex development show that sexual diversity is a natural part of human variation.

The patient's long-term symptoms were due to Sheehan's syndrome, which improved with hormone therapy.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Testosterone is key for male sexual function, and treating hormone imbalances can improve sexual issues.

Sex and stress steroids quickly change brain cell structures in the hippocampus.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

Antiandrogens might help prevent or treat COVID-19 by blocking the virus's entry into cells.

Ketoconazole is effective for treating various fungal infections and has new uses in dermatology, but oral use can have serious side effects.

Gonadal hormones may influence sex differences in play fighting in animals, but their effect on human spatial behavior is unclear and needs more research.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Hormone therapy can improve mental health and quality of life for people with gender dysphoria, but long-term effects need more research.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.