1 citations
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April 2023 in “Archives of Dermatological Research” This study proposes a grading system based on comorbidities and systemic involvement to assess the severity of dermatological emergencies.
September 2022 in “International Journal of Trichology” This study found that trichoscopic measurements of hair density and diameter are useful for assessing the severity of female pattern hair loss and its progression.
22 citations
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August 2013 in “International journal of gynaecology and obstetrics” This study found that GAGS scores for acne were higher in younger women with PCOS and a lower BMI, but showed no association with levels of androgen hormones.
July 2026 in “Journal of Cutaneous and Aesthetic Surgery” This study found that trichoscopic quantitative parameters reliably indicate the severity of female pattern hair loss and complement the Sinclair scale by offering a more objective and reproducible grading system.
2 citations
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December 2018 in “International Journal of Dermatology” This study developed a new semiquantitative grading scale for frontal and vertex androgenetic alopecia, which was found to be more sensitive and objective than existing classifications.
April 2026 in “Academic Dermatology” In this retrospective observational study, researchers found that the Dean Scale showed better diagnostic accuracy than the CTCAE scale for detecting clinician-reported therapeutic responses to minoxidil in patients with anticancer therapy-induced alopecia, but both scales had limitations in recording clinically significant hair regrowth.
April 2025 in “Journal of Cosmetic Dermatology” This study evaluated a new AI-linked imaging device for grading dandruff severity, finding high correlation with expert assessments and suggesting its potential application in other skincare areas due to its versatility and ease of use.
January 2020 in “Medpulse International Journal of General Medicine/Medpulse International Journal of Medicine” In this study, among 50 patients with premature hair graying, the combination of biotin, zinc, and calcium pantothenate showed no significant efficacy in treating the condition, and the researchers observed associations with other disorders such as anemia, alopecia areata, thyroid disorder, and vitiligo.
March 2026 in “International Journal of Homoeopathic Sciences” In this study, 10.25% of school children aged 5-15 in Belagavi were found to have premature greying of hair, with the majority showing mild severity according to the Graying Severity Score.
21 citations
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January 2014 in “International Journal of Trichology” This study observed that while dermoscopic features in alopecia areata for dark-skinned individuals align with existing literature, yellow dots appear more frequently and could help in grading disease severity.
April 2023 in “Journal of Investigative Dermatology” This study assessed an AI-based mobile app for evaluating androgenetic alopecia severity, finding that it achieved 94% accuracy compared to human dermatologists, while participants often underestimated their own hair loss severity.
26 citations
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December 2015 in “Journal of The European Academy of Dermatology and Venereology” This article introduces a new grading system called the FPHL Severity Index to better identify and monitor early stages of female pattern hair loss using clinical criteria.
December 2025 in “Chinese Medical Journal” This study developed a simplified multidimensional assessment scale for alopecia areata severity and systemic treatment initiation among Chinese patients, achieving expert consensus on relevant clinical indicators and conditions.
May 2021 in “Open Access Macedonian Journal of Medical Sciences” This study found that individuals with premature hair graying had significantly lower levels of antioxidants compared to controls, but the severity of graying did not significantly correlate with oxidative stress levels.
5 citations
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June 2019 in “Dermatopathology” This study found poor agreement among dermatopathologists in identifying and grading fibrosis in traction alopecia, suggesting the need for better diagnostic methods for early fibrosis detection.
17 citations
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January 2018 in “International Journal of Trichology” This study found that patients with premature hair graying had lower serum levels of iron, copper, and calcium, which correlated with the severity of graying.
April 2017 in “Journal of Investigative Dermatology” In this pilot study, researchers observed a correlation between clinical severity and histologic severity of lichen planopilaris, suggesting that an immunohistochemical scoring system could aid in grading disease activity.
3 citations
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January 2018 in “International Journal of Trichology” The authors concluded that their new grading system can effectively classify early female pattern hair loss and evaluate treatment progress.
9 citations
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January 2015 in “Annals of dermatology/Annals of Dermatology” This retrospective study concluded that alopecia areata in elderly patients showed mild severity and a favorable treatment response, with no link found between hair graying and the extent of hair loss.
In this study, researchers evaluated hirsutism in young females aged 18-24 using the modified Ferriman-Gallwey scoring system, finding that 52% showed mild to moderate-to-severe symptoms, often linked to menstrual irregularities and underlying endocrine disorders like polycystic ovary syndrome and thyroid issues.
6 citations
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March 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This study found that in Turkish participants, factors such as male gender, late-onset, and temporal-onset were linked with more severe hair graying.
June 2024 in “Benha Journal of Applied Sciences” This study suggests that ischemia-modified albumin may play a role in premature hair graying and vasogenic erectile dysfunction, potentially serving as indicators of susceptibility and severity.
March 2024 in “Skin research and technology” This study reported that newly established dermoscopic diagnostic and grading criteria for androgenetic alopecia are highly accurate, with sensitivity and specificity at 98.3% and 96.7%, respectively.
In this study, Neeli Bhringadi hair oil showed statistically significant improvements in hair growth rate, density, thickness, and reduction in premature graying on participants with androgenetic alopecia and hair graying over 120 days, supporting its potential use in integrative hair care.
26 citations
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June 2016 in “Pediatric Dermatology” This study found that premature hair graying in young Turkish men and women is associated with emotional stress, alcohol consumption, chronic diseases, and a family history of graying.
7 citations
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January 2018 in “PubMed” In this study, reduced serum levels of iron, copper, and calcium were associated with premature graying of hair, suggesting that supplementation might help, but more research is needed to fully understand the relationship.
46 citations
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December 2014 in “Journal of The American Academy of Dermatology” This study found that smoking, obesity, and family history are significant risk factors for premature hair graying in young men.
The document concludes that dermatology training and grading scales need to better represent dark-skinned individuals to improve diagnosis and assessment of skin conditions.
September 2024 in “Journal of Cutaneous and Aesthetic Surgery” This review focuses on the pharmacological properties, indications, contraindications, and safety profile of bicalutamide, a non-steroidal androgen receptor antagonist, in dermatological research, particularly its off-label use for improving female pattern hair loss as measured by Sinclair grading.
7 citations
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January 2016 in “Hair therapy & transplantation” This study reported significantly lower levels of serum iron, ferritin, and calcium in young patients with premature gray hair compared to controls, implying that supplementation might prevent further graying.