April 2026 in “Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi” This study found that patients with severe acne vulgaris had different systemic inflammatory indices and hematologic parameters compared to healthy individuals.
April 2024 in “Frontiers in medicine” This Delphi study found that moderate-to-severe alopecia areata in Poland, Czechia, Russia, and Türkiye significantly impacts quality of life and highlights an unmet need for more effective treatments.
January 2023 in “Revista Paulista de Pediatria” This case study reported the first diagnosis of IFAP syndrome in Brazil with molecular investigation, identifying a rare MBTPS2 gene variant and expanding the known mutational spectrum associated with the condition.
1 citations
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May 2015 in “Journal of The American Academy of Dermatology” Finasteride for hair loss in young men may significantly increase the risk of sexual dysfunction.
May 2015 in “Journal of The American Academy of Dermatology” Young men taking finasteride for hair loss have a higher risk of sexual dysfunction.
196 citations
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September 2016 in “JCI insight” This study explored the effectiveness of the oral JAK1/2 inhibitor ruxolitinib in treating patients with moderate-to-severe alopecia areata, building on prior success with JAK inhibitors in mice, but results are not reported in this abstract.
42 citations
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November 2018 in “Archives of dermatological research” Apremilast was not effective in treating moderate-to-severe alopecia areata.
20 citations
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January 2013 in “Evidence-based complementary and alternative medicine” This study found that TGPC plus CGT was more effective than CGT alone in reducing alopecia areata severity in children over 12 months, with similar safety profiles.
18 citations
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January 2017 in “Journal der Deutschen Dermatologischen Gesellschaft” This study reports that sequential high- and low-dose prednisolone therapy effectively promotes complete hair regrowth in 62% of children with severe alopecia areata, while minimizing severe side effects.
April 2026 in “Dermatology and Therapy” This study evaluated baricitinib 4 mg treatment in severe to very severe alopecia areata, reporting significant scalp hair regrowth by Week 52, especially in short-duration episodes, suggesting treatment should continue for at least a year before assessing failure.
November 2025 in “Clinical Cosmetic and Investigational Dermatology” This study evaluated the efficacy and safety of tofacitinib for treating severe alopecia areata in five patients, finding that three responded favorably with mild side effects, supporting its potential use based on existing research.
In this retrospective study, researchers found that baricitinib was effective for treating moderate to severe alopecia areata, with response rates in 24 patients comparable to existing real-world data, and no new safety concerns were identified.
April 2024 in “Frontiers in pharmacology” This study compared JAK inhibitors for moderate-to-severe alopecia areata and found brepocitinib 30mg and deuruxolitinib 12mg to be most effective, though deuruxolitinib may cause more adverse events. Further research is needed for long-term efficacy and safety.
56 citations
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January 2013 in “International journal of trichology” This case report suggests that zinc supplements may be necessary to improve hair loss in hypothyroidism patients being treated with thyroxine.
21 citations
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January 2013 in “Annals of dermatology/Annals of Dermatology” In this study, combination therapy with cyclosporine and PUVA for severe alopecia areata resulted in a majority of patients showing only fair to poor responses, though some improvements were noted.
March 2015 in “Polish Journal of Public Health” This study found that capillaroscopic patterns varied among patients with systemic scleroderma, psoriasis, psoriatic arthritis, and alopecia, suggesting potential microcirculation disturbances; however, no correlations were observed with serum angiogenic markers.
10 citations
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January 2020 in “Advances in Dermatology and Allergology” This study suggests that the gene rs27647 polymorphism may play a role in the pathogenesis of severe acne vulgaris in post-adolescent male patients.
September 2025 in “Clinical Cosmetic and Investigational Dermatology” In this randomized, placebo-controlled study, Kūlaris supplementation significantly improved quality of life for participants with mild-to-severe acne over 12 weeks, though no significant changes in general skin health measures were observed compared to placebo.
June 2024 in “Dermatology and Therapy” In this study, patients with alopecia areata who experienced sustained hair regrowth while being treated with baricitinib showed improvements in health-related quality of life and reductions in anxiety and depression symptoms over 104 weeks, according to the BRAVE-AA phase III trials.
March 2022 in “Nepal Journal of Dermatology Venereology & Leprology” In this prospective clinical trial, azathioprine with steroid minipulse therapy and methotrexate with steroid minipulse therapy both improved hair regrowth in alopecia areata patients, but methotrexate showed slightly higher efficacy.
December 2025 in “Clinical Cosmetic and Investigational Dermatology” In this report, a unique female presentation of IFAP syndrome is described, featuring musculoskeletal contractures but no photophobia, highlighting the importance of early detection and multidisciplinary care to improve outcomes and prevent disability.
July 2025 in “Journal of Investigative Dermatology” In this study, researchers analyzed data from male psoriasis patients and reported the association between psoriasis management medications and male infertility, noting the scarcity of existing data on this topic.
July 2009 in “Medical & surgical dermatology” Low-dose acitretin helps nail psoriasis, stem cells may treat scarring alopecia, Chinese men have lower baldness rates, lateral foldplasty is good for ingrown toenails, hair diameter helps diagnose female baldness, childhood trauma linked to alopecia areata, certain hair-weaving leads to scalp conditions in African American women, and new methods for hair research and understanding hair and sweat gland development were introduced.
44 citations
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January 2002 in “American Journal of Clinical Dermatology” This review discusses adverse cutaneous drug reactions associated with antidepressants and provides guidance on managing these reactions, but it reports no new clinical findings; the authors recommend cautious use and alternative treatment if reactions occur.
49 citations
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August 2022 in “Frontiers in Immunology” This paper discusses the evolving understanding of psoriasis pathogenesis with no new clinical findings; the authors highlight the role of T-cell plasticity and regulatory cells, calling for further clinical applications using single-cell technologies.
14 citations
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January 2020 in “Skin appendage disorders” This study found that a shampoo containing 0.075% broad-spectrum cannabidiol significantly reduced scalp inflammation and symptoms in subjects with mild to moderate scalp psoriasis or seborrheic dermatitis within two weeks.
July 2026 in “Journal of the American Academy of Dermatology” Severe alopecia areata in children greatly affects their mental and social well-being, and addressing these challenges is crucial.
June 2025 in “Dermatopathology” This study reports that SARS-CoV-2 infection, COVID-19 vaccination, and off-label dupilumab treatment may exacerbate psoriasis, with overlapping inflammatory pathways involving cytokines like IL-17 and TNF-α. Histopathological similarities between psoriasis flares and COVID-19 skin manifestations were noted, suggesting a potential connection requiring further research.
July 2023 in “Journal of exploratory research in pharmacology” In this case report, a 47-year-old man with extensive psoriasis saw significant improvement in scaling and itching after using a new lotion containing clobetasol and other ingredients for one week, but further research is needed to confirm these findings.
July 2018 in “Elsevier eBooks” This review discusses various causes and treatments of scalp pruritus, distinguishing between conditions with primary skin lesions and those without, but provides no new clinical results.