July 2022 in “International Journal of Health Sciences (IJHS) (En línea)” In this study, researchers found that serum dihydrotestosterone levels were significantly lower in individuals with Type 2 Diabetes compared to healthy controls, with 90% of diabetics displaying subnormal levels.
9 citations
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February 2020 in “International Journal of Endocrinology” This study found that men with early-onset androgenetic alopecia and certain risk factors may have worse gonadal steroidogenesis and an increased likelihood of developing gonadal dysfunction, suggesting a male equivalent of polycystic ovarian syndrome.
February 2019 in “Journal of Pakistan Association of Dermatology” This study found that abnormal serum lipid levels were prevalent among male patients with androgenetic alopecia, with high triglycerides and low HDL observed frequently.
February 2024 in “Heliyon” In this study, AGA patients exhibited distinct lipidomic profiles and higher metabolic syndrome prevalence compared to controls, with certain lipids correlated to key AGA-related factors like DHT, PGD2, and TGF-β1.
105 citations
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January 2010 in “Mediators of Inflammation” This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.
10 citations
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March 2022 in “Communications biology” In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.
2 citations
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April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.
506 citations
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March 2005 in “The Journal of Clinical Endocrinology and Metabolism” This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.
17 citations
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January 2014 in “Journal of Clinical and Diagnostic Research” This study found that patients with oral lichen planus and oral lichenoid reactions have higher levels of serum cholesterol and LDL-C than healthy individuals, suggesting a potential elevated risk for cardiovascular disease.
December 2025 in “Journal of Skin and Stem Cell” This study found a higher prevalence of lipid abnormalities in individuals with androgenetic alopecia, especially in severe cases, highlighting the need for early screening and treatment to prevent cardiovascular complications.
March 2020 in “Journal of the turkish academy of dermatology” In this study, no significant difference was found in serum triglyceride and HDL cholesterol levels between male patients with androgenetic alopecia and those without.
1 citations
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October 2024 in “Cureus” This study reported that women with polycystic ovarian syndrome have higher serum irisin levels, which are associated with metabolic and hormonal imbalances, including hyperandrogenism, total cholesterol, and visceral fat.
32 citations
,
January 2017 in “PLoS ONE” This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.
2 citations
,
April 2021 in “International Journal of Pharmaceutics” This study concluded that a liquid serum formulation delivered two fluorescent dyes to deeper follicular regions more effectively than nanoparticle systems.
7 citations
,
April 2018 in “Cosmetics” This study found that the medulla of Japanese hair contains unsaturated lipids such as squalene and oleic acid, which may contribute to hair glossiness.
12 citations
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February 2006 in “Lipids” This study found that in Japanese, German, and American females, changes in hair lipid patterns with age may reflect alterations in sebum excretion and affect hair texture.
15 citations
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October 2016 in “Journal of The European Academy of Dermatology and Venereology” This meta-analysis found that patients with androgenetic alopecia have significantly abnormal lipid profiles, which could contribute to the link between this condition and cardiovascular diseases.
40 citations
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June 2011 in “Journal of biological chemistry/The Journal of biological chemistry” This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.
October 2011 in “Iranian Journal of Dermatology” This study found that men with androgenic alopecia had significantly higher levels of lipoprotein (a), a risk factor for coronary artery disease, compared to men with normal hair.
1 citations
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September 2016 in “Springer eBooks” This article reports no new data; it describes the role of sebum in influencing the skin microbiome and epithelial tissues and discusses its altered composition during transit through the sebaceous duct.
71 citations
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January 2014 in “Journal of Proteome Research” In this study, distinct metabolic profiles were identified in women with PCOS, suggesting potential biomarkers for diagnosis based on changes in lipid and androgen metabolism.
1 citations
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February 2013 in “African Journal of Pharmacy and Pharmacology” This study found that in patients with androgenetic hair loss, taking 1 mg of finasteride daily significantly raised triglyceride levels and decreased HDL levels after 3 and 6 months.
45 citations
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February 2011 in “Journal of the European Academy of Dermatology and Venereology” This study found that patients with lichen planus had significantly higher levels of triglycerides, total cholesterol, and LDL-C, and lower HDL-C compared to healthy controls, suggesting an association with dyslipidaemia.
31 citations
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February 2021 in “Nutrients” This study found that curcumin may improve glycemic control and certain aspects of lipid metabolism in patients with polycystic ovary syndrome.
20 citations
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June 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found that long-term dutasteride therapy in men with benign prostatic hyperplasia worsened erectile dysfunction, reduced testosterone levels, and increased blood glucose and lipid profile, indicating negative metabolic impacts.
May 2026 in “Global Translational Medicine” This study found that ethanol extract of Syzygium aromaticum (clove) leaves significantly improved lipid profiles and increased body weight in testosterone-induced benign prostatic hyperplasia rats, suggesting potential anti-hyperlipidemic effects and modulation of body weight through metabolic activity.
March 2024 in “Revista Ciências da Saúde CEUMA” This study found that administering testosterone increased the expression of sexual behavior and elevated serum testosterone and DHT levels in female capuchin monkeys, hinting at potential insights into testosterone use and its risks in humans.
166 citations
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March 2007 in “Hypertension” In this study, hyperandrogenemia in young women with polycystic ovary syndrome was linked to higher blood pressure, independent of factors like age, insulin resistance, obesity, or dyslipidemia.
July 2019 in “International journal of contemporary medical research” This study found that dyslipidemia was more common in male patients with androgenetic alopecia than in controls, particularly among those with severe AGA, suggesting a higher risk of altered serum lipids.
6 citations
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May 2019 in “Journal of pharmaceutical sciences” This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.