506 citations
,
March 2005 in “The Journal of Clinical Endocrinology and Metabolism” This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.
142 citations
,
February 1985 in “Fertility and sterility” This study found that spironolactone reduced serum androstenedione and anagen hair shaft diameter in hirsute patients but did not significantly alter unbound testosterone levels, suggesting its effects are primarily peripheral.
77 citations
,
October 2007 in “International Journal of Andrology” This study found that testosterone replacement, with or without finasteride, did not lead to significant cognitive improvements over 36 months in healthy older men without prior cognitive impairment.
72 citations
,
April 2008 in “The Journal of urology/The journal of urology” This study found that 1-year use of 5alpha-reductase inhibitors, dutasteride or finasteride, significantly lowered dihydrotestosterone levels without adversely affecting bone density, lipids, or hemoglobin in normal men.
65 citations
,
October 1999 in “Journal of The American Academy of Dermatology” In this study, finasteride doses as low as 0.2 mg per day significantly reduced both scalp skin and serum DHT levels in men with androgenetic alopecia.
42 citations
,
December 2015 in “International Journal of Clinical Pharmacology and Therapeutics” This study found that applying a novel 0.25% finasteride solution to the scalp can effectively reduce scalp DHT levels in men with androgenetic alopecia, potentially reducing systemic side-effects.
37 citations
,
March 2014 in “Journal of Trace Elements in Medicine and Biology” This study reported that Turkish males with male pattern androgenetic alopecia had significantly lower zinc and copper levels in their hair compared to healthy controls, suggesting these imbalances may play a role in the condition's etiology.
32 citations
,
May 1987 in “The Journal of Clinical Endocrinology & Metabolism” This study found that salivary testosterone concentrations correlated better with hirsutism in women compared to serum testosterone measures, suggesting it may be an effective method for assessing bioavailable testosterone.
23 citations
,
February 2017 in “Journal of dermatology” This meta-analysis suggests that patients with alopecia areata have lower serum levels of zinc and selenium compared to healthy controls, which may be important risk factors for the condition.
19 citations
,
April 2018 in “Clinical cardiology” This study found that among older men, low levels of free dihydrotestosterone were associated with an increased risk of developing atrial fibrillation.
18 citations
,
January 1985 in “Acta Obstetricia Et Gynecologica Scandinavica” In this study of hirsute women, researchers found that correlations between hirsutism and hyperandrogenism were observed only in patients with a low LH/FSH ratio.
11 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.
11 citations
,
April 2020 in “Andrology” This study found that testosterone replacement therapy, especially intramuscular administration, significantly increased PSA levels compared to placebo, while a significant correlation between PSA and testosterone was observed in non-BPH patients.
10 citations
,
February 2008 in “International Journal of Andrology” This study found that a 400-mg dose of oral testosterone with dutasteride increases serum testosterone levels for 8–10 hours in hypogonadal men, with the nanomilled formulation unaffected by food, suggesting a practical twice-daily therapy option.
8 citations
,
January 2024 in “Journal of Human Reproductive Sciences” This study found that serum zinc levels were lower in PCOS subjects compared to normal controls, suggesting zinc may play a vital role in PCOS pathophysiology.
6 citations
,
January 2020 in “Postepy Dermatologii I Alergologii” This article recommends assessing serum ferritin and vitamin D levels in patients with diffuse hair loss before starting treatment, but it reports no new clinical results.
6 citations
,
May 2016 in “Urolithiasis” This study found that the risk of urinary stone disease increased significantly in patients with severe androgenetic alopecia, and that testosterone deficiency was more frequent among these patients.
6 citations
,
April 2011 in “British journal of oral & maxillofacial surgery/British journal of oral and maxillofacial surgery” This study found that serum testosterone levels significantly increased during major head and neck surgeries in maxillofacial surgeons, influenced by factors like tumor size and procedural complexity.
5 citations
,
August 2018 in “Sexual Medicine Reviews” In this review and meta-analysis, the authors concluded that 5α-reductase inhibitor therapy is not consistently associated with significant increases in serum testosterone levels in men.
4 citations
,
August 2024 in “International Journal of Impotence Research” In this study using the TriNetX Research Network, men with low serum testosterone levels were found to have an increased risk of developing an initial kidney stone, particularly in those aged 33-44, compared to men with normal testosterone levels.
2 citations
,
November 2019 in “Case reports in women's health” In this study, two women with hyperandrogenic symptoms were found to have ovarian Leydig cell tumors after selective ovarian venous sampling and salpingo-oophorectomy, leading to a decline in testosterone levels post-surgery.
1 citations
,
January 2023 in “International journal of urology” In this study, researchers observed that lower serum zinc concentrations were associated with decreased serum testosterone levels, but no link was found with sexual function questionnaire scores.
1 citations
,
October 2021 in “Benha Journal of Applied Sciences” This study found that individuals with acne vulgaris had significantly higher serum total thiol and thiol disulfide levels, as well as a reduced total thiol/thiol disulfide ratio, compared to healthy controls.
1 citations
,
April 2021 in “International Journal of Research in Dermatology” This study found low serum ferritin and vitamin B12 levels in a significant portion of women with chronic telogen effluvium, while vitamin D deficiency was less common.
1 citations
,
March 1995 in “Pharmacoepidemiology and drug safety” This study found that female isotretinoin users who also took oral contraceptives were more likely to experience elevated triglyceride or cholesterol levels.
July 2026 in “International Journal of Clinical & Experimental Dermatology” This exploratory pilot study reported that using a 2% Oleosome-FGF-2 fusion extract scalp serum twice daily for 84 days in women with telogen effluvium and brittle hair improved hair density, anagen/telogen ratio, hair shaft thickness, and scalp hydration compared to a placebo.
February 2024 in “Malahayati Nursing Journal” This study found that hirsutism in women is associated with elevated androgen hormone levels and increased serum TNFα, suggesting a link between androgen-driven inflammatory responses and excessive hair growth.
September 2010 in “European Urology Supplements” Opioid use may lower PSA levels, suggesting a possible role in prostate cancer control; PSA testing is useful for detecting prostate cancer; serum triglycerides are not linked to prostate cancer risk; and higher urethral PSA levels may be associated with local hormone activity.
September 2010 in “European Urology Supplements” Serum triglyceride levels are not linked to prostate cancer risk.
January 2005 in “Journal of Investigative Medicine” This study found that testosterone therapy improved physical performance, strength, lean body mass, and serum cholesterol in older men with low testosterone levels, with or without the addition of finasteride.