195 citations,
November 2019 in “Clinica Chimica Acta” High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.
44 citations,
June 2012 in “Endocrinology” High levels of androgens during early development may cause PCOS-like symptoms.
35 citations,
January 2011 in “Clinical Endocrinology” Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.
33 citations,
November 2012 in “Journal of The American Academy of Dermatology” FPHL common in Taiwanese women; risk factors include BMI, high glucose, early puberty, fewer childbirths, oral contraceptives, and UV exposure.
24 citations,
March 2017 in “Archives of Gynecology and Obstetrics” The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
21 citations,
September 2017 in “Journal of Obstetrics and Gynaecology Research” Chromium supplements don't improve insulin, hormone levels, or cholesterol in women with PCOS but raise testosterone levels.
19 citations,
January 2017 in “Hormone Molecular Biology and Clinical Investigation” High levels of male hormones are very common in women with PCOS and affect their metabolism differently depending on their weight.
19 citations,
March 2012 in “Clinical Endocrinology” FAI values above 6.4 may suggest high androgen levels and increased metabolic risks in Chinese women of reproductive age.
17 citations,
February 2019 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
6 citations,
June 2017 in “Reproductive Biomedicine Online” Chinese women with PCOS have higher androgen levels, which change with age and weight.
2 citations,
April 2019 in “Медицинский совет” Combined oral contraceptives improve skin, hormone levels, and quality of life in women with PCOS.
Resveratrol improved hormone levels, menstrual cycles, hair loss, and ovarian function in PCOS patients.
September 2018 in “Fertility and Sterility” High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.
October 2015 in “Elsevier eBooks” Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.
January 2011 in “Yearbook of Dermatology and Dermatologic Surgery” Hair relaxers are linked to reduced cystine levels and potential hair damage.
January 2011 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” Hyperthyroidism can hide signs of high androgen levels in females.
August 1994 in “Molecular Endocrinology” Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.
195 citations,
April 2005 in “Journal of biological chemistry/The Journal of biological chemistry” The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.
63 citations,
March 2011 in “Clinical Endocrinology” Evaluate postmenopausal women with high androgen levels using medical history, physical exams, lab tests, and imaging to manage health risks.
52 citations,
June 2013 in “The Journal of Clinical Endocrinology and Metabolism” The research found that anovulatory young women have higher androgen and hormone levels than those who ovulate, suggesting immature hormonal regulation rather than a specific condition.
33 citations,
January 2018 in “The Journal of Clinical Endocrinology & Metabolism” Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.
15 citations,
October 2016 in “Journal of The European Academy of Dermatology and Venereology” People with hair loss have worse cholesterol levels, possibly linking hair loss to heart problems.
4 citations,
September 2013 in “Expert Review of Endocrinology & Metabolism” Different types of polycystic ovary syndrome show varying levels of insulin resistance, with the 'PHO' type being the most insulin resistant.
1 citations,
January 2021 in “Journal of biological chemistry/The Journal of biological chemistry” FLCN helps control iron levels in cells.
September 2008 in “Fertility and Sterility” Exposure to fatty acids significantly increased androgen levels in female dogs, suggesting a link to conditions like insulin resistance and PCOS.
92 citations,
November 2003 in “The Journals of Gerontology” Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.
29 citations,
February 2018 in “Genetics research international” Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.
25 citations,
May 2021 in “Journal of exposure science & environmental epidemiology/Journal of exposure science and environmental epidemiology” Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.
6 citations,
August 2009 in “Mini-reviews in Medicinal Chemistry” Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.
5 citations,
May 2017 in “Journal of the European Academy of Dermatology and Venereology” The study found no significant difference in stress hormone levels between people with alopecia areata and healthy individuals, suggesting that the disease is not caused by an overactive stress response system.