39 citations,
September 2017 in “The Open Rheumatology Journal” Low serum complement levels in SLE patients don't always match with disease flares; monitoring C3 and C4 is useful, but cell-bound complement products might better indicate disease activity.
2 citations,
January 2012 in “PubMed” The study evaluated the efficacy of mycophenolate mofetil (MMF) in treating juvenile onset severe lupus nephritis. Twelve children (mean age 12.6 years) underwent 6 months of induction therapy with MMF and prednisolone, resulting in significant improvements in urine protein, serum anti-double-stranded DNA antibody, renal function, albumin, and serum C3 and C4 levels (p < 0.05). Ten children continued with 18 months of maintenance therapy, during which no renal flares occurred, and the mean prednisolone dose was reduced to 9.2 mg/day. Among 5 patients who had a second biopsy, 4 showed significant histological improvement. Major infections were reported in 5 patients, including Herpes zoster, bacteremia, and hair loss. MMF was concluded to be an effective therapy for this condition.
3 citations,
January 2023 in “The Egyptian Rheumatologist” Macrophage activation syndrome can be a deadly first sign of systemic lupus erythematosus.
1 citations,
June 2016 in “Annals of the rheumatic diseases” Retinoids may help treat lupus nephritis and reduce steroid use.
165 citations,
September 2001 in “Genes & development” CDP is crucial for lung and hair follicle cell development.
39 citations,
June 2019 in “Toxins” Bee venom might be a good alternative treatment for various skin conditions because it has many healing properties.
29 citations,
February 2019 in “Journal of the European Academy of Dermatology and Venereology” Trichoscopy is useful for diagnosing and monitoring systemic lupus erythematosus, with certain hair and scalp changes indicating more active disease.
12 citations,
April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia” Women with Systemic Lupus Erythematosus should have closely monitored pregnancies and avoid certain medications to improve their pregnancy outcomes.
5 citations,
May 2023 in “Frontiers in immunology” Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
2 citations,
June 2016 in “Journal of skin and stem cell” Wet cupping blood has different components than regular venous blood, which might affect skin disorder treatments.
22 citations,
January 2012 in “Mediators of inflammation” Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.
January 2023 in “Journal of Integrative Medicine and Research” Vitiligo and lupus can occur together, requiring careful treatment to manage both conditions.
7 citations,
November 1977 in “JAMA” A woman got a serious strep infection from an IUD, likely passed from her husband's infected throat during sexual activity.
7 citations,
July 2019 in “Scientific Reports” Finasteride helps reduce heart enlargement in heart failure patients.
February 2024 in “Journal of dermatology” CGF therapy may help hair regrowth and improve scars in DLE patients.
January 2017 in “Journal of Investigative Dermatology Symposium Proceedings” The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.
64 citations,
August 2016 in “Journal of Immunology” Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.
87 citations,
July 2012 in “Expert Review of Clinical Immunology” Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.
The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.
37 citations,
January 1993 in “Yakugaku zasshi” Ginkgo biloba leaf extract may help hair regrowth and improve heart health.
5 citations,
August 1981 in “Archives of Dermatology” Alopecia areata may be caused by the immune system attacking hair follicles.
June 2020 in “Annals of the Rheumatic Diseases” Patients with Systemic Sclerosis have much higher levels of GDF-15, which could help predict organ involvement and guide treatment.
16 citations,
May 1998 in “International Journal of Dermatology” Stress hormones like cortisol may trigger psoriasis flare-ups.
5 citations,
September 2021 in “Journal of cosmetic dermatology” People with alopecia areata often have abnormal thyroid hormones, thyroid antibodies, antinuclear antibodies, low vitamin D, and high C-reactive protein levels.
62 citations,
January 2013 in “Skin Pharmacology and Physiology” Low iron and vitamin D levels are linked to hair loss in women.
4 citations,
January 2015 in “Journal of microbial & biochemical technology” Biotin helps regulate proteins in the blood, which may explain its role in hair growth.
2 citations,
August 2020 in “Journal of Cosmetic Dermatology” Higher granulysin levels in the blood are linked to more severe hair loss in alopecia areata patients, and these levels decrease after effective treatment.
December 2017 in “Revista Brasileira de Saúde Materno Infantil” Pregnant women with Systemic Lupus Erythematosus have a higher risk of blood clotting problems.
131 citations,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.
37 citations,
November 2003 in “Veterinary pathology” Hair loss in mice starts with immune cells damaging hair roots before it becomes visible.