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Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

The document explains how male reproductive hormones work and affect the body.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Testicular microlithiasis may increase the risk of testicular cancer and patients with it should be closely monitored.

Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.

Testosterone is crucial for development, growth, and various body functions in mammals.

The conclusion is that a systematic approach is key for treating symmetrical alopecia in dogs, but treatment may not always be necessary.

Ficus carica extract improved fertility in rats and may help with certain health conditions.

A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.

Some ovarian tumors can cause masculinization, and it's important to check for various causes when this symptom is present.

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

High levels of cortisol in hair show long-term stress which can lower fertility in animals.

Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Medical treatments like chemotherapy and radiotherapy can harm sperm production, so freezing sperm before treatment is important for men who want children later.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

Some common medications can harm male fertility, but many effects can be reversed.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

New genes and pathways are important for testosterone production and male sexual development.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

Men with early hair loss have similar hormone levels to women with PCOS, possibly increasing risk of obesity and heart issues.