18 citations
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September 1972 in “British Journal of Pharmacology” In this study on male rats, parachlorophenylalanine treatment induced hypersexual behavior and hair loss linked to increased social interaction but had no effect on brain serotonin when testosterone was used instead.
15 citations
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September 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses OCD spectrum disorders with dermatological symptoms, emphasizing their clinical features, neurobiology, and treatment options, while noting the need for more controlled studies.
11 citations
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November 1991 in “Journal of Neuropathology & Experimental Neurology” This study found that brindled mottled mice, a model of Kinky hair syndrome, exhibited abnormal development of catecholamine neurons, with increased TH-immunoreactive neurons and altered neurochemical profiles compared to controls.
8 citations
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November 2011 in “Journal of Medical Case Reports” This case report describes a 23-year-old Asian woman with fluoxetine non-responsive trichotillomania who showed significant improvement with bupropion and cognitive behavior therapy, though confirmation in larger trials is needed.
6 citations
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February 2019 in “Scientific reports” This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.
4 citations
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January 2015 in “Case Reports in Urology” This case report describes a 66-year-old male with benign prostatic hyperplasia who developed urinary incontinence after starting venlafaxine, which resolved upon discontinuation of the medication.
2 citations
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October 2023 in “Science advances” In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.
2 citations
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October 2015 in “Indian journal of science and technology” This study found that SM-215 applied to mice increased hair follicle activity and capillary presence, promoting hair growth compared to non-treatment.
2 citations
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January 2011 in “Andrologia” This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.
2 citations
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December 2019 in “Neurobiology of Stress” This review discusses the potential link between early postnatal allopregnanolone levels and vulnerability to drug abuse in adulthood, noting a need for more in-depth studies to confirm this relationship.
1 citations
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July 2015 in “The European research journal” This case report describes reversible hair loss in a patient taking aripiprazole, suggesting this side effect may be common among psychotropic medications.
February 2026 in “Molecules” This study developed a sensitive method for analyzing nine biomarkers in hair, revealing an association between chronic tobacco smoke exposure and stress, highlighting its potential use in understanding the relationship between long-term tobacco exposure and chronic stress.
December 2025 in “Molecular Pain” This study identified that the MC-5-HT-HTR2A axis plays a role in chronic pruritus in a mouse model of SADBE-induced allergic contact dermatitis, suggesting potential for therapeutic targeting.
December 2025 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)” In this review, researchers examined nine studies on botulinum toxin type A's effects on biomarkers in chronic head and neck conditions, finding significant, though low to moderate certainty, changes in markers like CGRP and serotonin associated with inflammation and mood disorders.
September 2025 in “Journal of Psychiatry Spectrum” This case report describes a rare instance of gynecomastia in a male patient undergoing mirtazapine treatment for depression, suggesting the drug as a probable cause after ruling out other factors.
In this study, researchers synthesized the fictional compound 1-hydroxyindole and discovered its potential medical applications, including anti-aging properties, itch relief for atopic dermatitis, and as a stronger treatment for dementia compared to cilostazol. Additionally, they found that 1-methoxyindole derivatives function as anticancer agents in diets.
December 2024 in “Journal of Clinical Medicine” This review explores the hormonal factors linking polycystic ovary syndrome and psychiatric disorders, such as eating disorders, emphasizing a bidirectional relationship that necessitates a multidisciplinary treatment approach; it reports no new clinical results.
November 2024 in “Journal of Investigative Dermatology” Skin and hair cells release serotonin and histamine naturally, which could help improve skin health.
This review supports iron deficiency anemia as a valid cause of chronic generalized pruritus and suggests potential mechanisms by which iron deficiency may lead to pruritus, but reports no new clinical results.
November 2023 in “International journal of biology, pharmacy and allied sciences” This review highlights scientific information about the medicinal uses and phytochemistry of Musa paradisiaca plant parts, which are traditionally used in human medicine to treat conditions such as diabetes, diarrhoea, hypertension, and ulcers, and exhibit various pharmacological activities including antidiabetic, antioxidant, and wound healing effects.
This study found that neonatal administration of Allopregnanolone may mitigate some behavioral effects of early maternal separation in adolescence, but also lead to similar adverse effects as the separation in adulthood.
March 2020 in “European Journal of Pediatric Dermatology” This article highlights that isotretinoin can rarely cause persistent sexual dysfunction, similar to finasteride and certain antidepressants, a side effect not mentioned in the drug’s data sheet.
January 2017 in “International journal of science and research” This review discusses treatment options for trichotillomania, focusing on cognitive-behavioral interventions and promising developments in combined pharmacotherapy and therapy approaches, but reports no new findings.
November 2010 in “Clin-Alert” Monitoring for adverse effects in clinical treatments is crucial.
October 2022 in “Biomolecules” This study found that in male rats, chronic finasteride treatment reduced allopregnanolone levels, which, upon drug withdrawal, correlated with increased pro-inflammatory cytokines and altered neurotransmitter levels.
83 citations
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January 2001 in “American journal of clinical dermatology” This review discusses the clinical features of trichotillomania and the challenges in its diagnosis and treatment, reporting no new clinical findings while highlighting the need for specialized therapy and better therapeutic options.
41 citations
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March 2010 in “Psychology Research and Behavior Management” This review discusses the complex interplay between the nervous system and skin conditions, highlighting various treatment strategies, but reports no new research findings.
38 citations
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April 2017 in “Journal of The American Academy of Dermatology” This review discusses psychocutaneous syndromes, detailing their classifications and management strategies, but reports no new clinical findings; it underscores dermatologists' role in these cases.
30 citations
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August 2018 in “Dermatology and Therapy” This review discusses the diagnostic and treatment challenges of trichotillomania and emphasizes the need for better-designed studies to optimize treatment approaches.
26 citations
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January 2017 in “Acta dermato-venereologica” This review examines the use of monoaminergic antidepressants for inflammatory skin disorders and reports they may reduce dermatological symptoms, suggesting a potential role beyond treating psychiatric conditions.