17 citations
,
April 2006 in “Brain Research” This study found that stimulation with certain neurotransmitters and hormones suggests the involvement of 5α-reduced neurosteroids in glial cell differentiation in rat C6 glioma cells.
17 citations
,
January 1997 in “Cell and Tissue Research” This study found that a serum-free DMEM-F12 medium with 45% oxygen best supports in vitro development and differentiation of human fetal skin, closely mimicking the in vivo state.
16 citations
,
January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that premature hair graying is strongly associated with a family history, Vitamin B12 deficiency, and hypothyroidism, with onset as early as 5 years in patients in Gurugram, India.
16 citations
,
May 2009 in “Journal of child neurology” In this study, valproic acid treatment did not significantly affect serum biotinidase enzyme activity in children, but was associated with hair loss in some patients, which resolved with biotin supplementation.
16 citations
,
January 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that serum PSA levels are higher in hirsute women and can be significantly reduced by antiandrogen treatment, suggesting PSA as a marker of androgen action in females.
15 citations
,
September 2023 in “International Journal of Microbiology Research” This study suggests that anti-Müllerian hormone (AMH) is the most promising biomarker for diagnosing polycystic ovary syndrome (PCOS), especially in women with phenotype A and D.
15 citations
,
January 2018 in “Indian Journal of Dermatology” This study reported that women with female androgenetic alopecia had significantly lower zinc levels in both serum and hair, and lower hair iron levels, compared to healthy controls.
15 citations
,
January 2016 in “International journal of trichology” This study found that female students experiencing diffuse hair fall had significantly lower Vitamin D3 levels compared to healthy controls.
15 citations
,
May 2006 in “Brain & development” The authors concluded that administering biotin may help prevent alopecia caused by reduced biotinidase activity during valproic acid therapy in rats.
15 citations
,
May 1986 in “Journal of the American Veterinary Medical Association” In this study, a dog with alopecia and a Sertoli cell tumor showed hyperprogesteronemia, and its hair regrew after castration, with progesterone levels reducing toward normal.
14 citations
,
July 2021 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This study found that alopecia areata patients had higher baseline interleukin levels, which significantly decreased with tofacitinib treatment, though this change did not correspond to disease severity improvement.
14 citations
,
January 2020 in “Advances in Dermatology and Allergology” This study found that elevated serum levels of IL-15 in active alopecia areata patients are correlated with disease severity, suggesting it plays a role in disease pathogenesis.
14 citations
,
January 2013 in “Journal of the Egyptian Women's Dermatologic Society /Journal of the Egyptian Women's Dermatologic Society”
14 citations
,
January 2013 in “Journal of Cutaneous Medicine and Surgery” This study describes permanent scalp alopecia in patients receiving chemotherapy, radiation, or both, and highlights the need for further research to identify causative factors and mitigation strategies.
14 citations
,
March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that serum MIF levels were significantly higher in patients with extensive alopecia areata compared to those with mild alopecia areata and healthy individuals.
14 citations
,
July 1983 in “Acta Dermato Venereologica” This study describes a method for serially cultivating adult human hair follicle keratinocytes using a specific growth substrate and cryogenic storage, enabling subculture and immunofluorescence studies.
13 citations
,
December 2016 in “Egyptian Journal of Basic and Applied Sciences” This study found that patients with alopecia areata had significantly lower serum levels of 25-hydroxy vitamin D compared to control subjects.
13 citations
,
March 2014 in “Journal of Clinical Laboratory Analysis” This study found that patients with alopecia areata had significantly higher serum MIF levels compared to healthy controls, which correlated with greater disease severity and duration.
13 citations
,
May 2012 in “Cutaneous and ocular toxicology” In this study, researchers found no significant differences in vitamin B12, folate, and homocysteine metabolism between patients with alopecia areata and controls, suggesting no association with vitamin B12 deficiency.
13 citations
,
September 2009 in “Heart & Lung” This case study reports the first known instance of adult Kawasaki's disease presenting with highly elevated serum ferritin levels and splenomegaly, emphasizing its consideration in differential diagnoses for adults with persistent rash, fever, and specific clinical features.
13 citations
,
August 2007 in “Journal of Investigative Dermatology” Mouse hair can regrow in a special lab setup without serum.
13 citations
,
August 1999 in “Journal of Investigative Dermatology” This study found that bikunin is expressed in human keratinocytes and may play a role in regulating keratinocyte function during mitosis or inflammation.
12 citations
,
September 2021 in “Stem Cell Reviews and Reports” This study suggests that StemMACS MSC Expansion Media is more suitable than PowerStem MSC1 media for expanding therapeutic adipose-derived mesenchymal stem cells, with less expression of negative markers and better chromosomal stability.
12 citations
,
February 2020 in “The Journal of Clinical Endocrinology & Metabolism” This study found that a self-assessed modified Ferriman-Gallwey score of 10 or higher indicates excess body hair, and suggests androstenedione measurement should accompany testosterone when evaluating hyperandrogenism.
12 citations
,
May 2005 in “Fertility and Sterility” This study suggests that insulin levels may influence ovarian volume in women with idiopathic hirsutism who have normal ovulatory cycles and androgen levels.
12 citations
,
January 1998 in “Endocrine journal” Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.
11 citations
,
April 2023 in “Annals of General Psychiatry” This study found that males treated with serotonergic antidepressants had an increased risk of erectile dysfunction, with an adjusted odds ratio of 3.2, and the risk for post-SSRI sexual dysfunction was 0.46%, emphasizing the importance of informed consent due to these potential irreversible side effects.
11 citations
,
February 2022 in “Actas Dermo-Sifiliográficas” This study reports serious adverse effects resulting from compounding errors when using low-dose oral minoxidil to treat alopecia.
11 citations
,
April 2020 in “Andrology” This study found that testosterone replacement therapy, especially intramuscular administration, significantly increased PSA levels compared to placebo, while a significant correlation between PSA and testosterone was observed in non-BPH patients.
11 citations
,
February 2019 in “Journal of Cosmetic Dermatology” This study found that male androgenetic alopecia patients had significantly lower serum zinc levels and suboptimal biotin levels compared to healthy controls, suggesting the potential value of zinc and biotin supplementation.