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30 / 1000+ resultsresearch Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
This study identified Azithromycin and Roxithromycin as novel senolytic antibiotics that effectively target and reduce senescent human fibroblast cells.
research Wound healing: cellular mechanisms and pathological outcomes
This review explores the cellular mechanisms of tissue repair and discusses how advancements in understanding wound pathology could lead to the development of more effective therapies for chronic, non-healing wounds, which are prevalent among individuals with diabetes and aging.
research Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents
This review discusses cellular senescence in human skin, detailing both beneficial and detrimental effects and suggesting the potential for therapies targeting senescence-related skin disorders, but reports no new clinical results.
research Cellular senescence in tissue repair: every cloud has a silver lining
This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.
research Oncogenic senescence: a multi-functional perspective
This workshop review discusses the dual role of cellular senescence in cancer, highlighting both its anticancer effects and pro-tumorigenic potential, while reporting no new research results.
research Frontiers in Topical Photoprotection
This review synthesizes research on solar radiation's multifaceted effects on skin and recent advancements in sunscreen technology, including formulation, testing methods, and the use of AI, to inform future sun protection product development.
research Cellular Senescence and Aging in Myotonic Dystrophy
This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.
research Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective
This review discusses the complex correlation between cellular senescence and PCOS, emphasizing senescence markers, mechanisms, and potential anti-senescence therapies, but reports no new clinical results.
research Platelet Immune Interactions, Lifespan, and Senescence
This study highlights the role of platelets in immune interactions and severe adenovirus infection, noting that activated platelets have a shorter lifespan. Results suggest potential for developing therapies targeting platelet senescence and immunologic mechanisms.
research A review on skin aging: mechanisms and therapeutic strategies
This literature review indicates that skin aging involves complex interactions of both internal and external factors, leading to oxidative stress and cellular damage. The authors report promising results from novel anti-aging interventions, including antioxidants, senolytics, and herbal preparations, for slowing skin aging progression.
research A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies
This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.
research Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging
In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.
research Restoration of hair follicle inductive properties by depletion of senescent cells
In this study, researchers found that treating senescent human dermal papilla cells with dasatinib and quercetin improved their ability to regenerate hair follicles by depleting senescent cells and enhancing inductive potency, suggesting potential clinical applications for senolytic treatments in cell-based hair restoration therapies.
research 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons
This study explored the effects of red ginseng-derived components on aging skin cells and found they do not have senolytic properties but can alleviate signs of cellular aging and improve skin cell function by reducing senescence markers and inflammation.
research 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs
Bioengineered skin models aging well, useful for studying aging and testing treatments.
research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives
This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.
research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle
This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.
research 0950 Exploring hair aging through ex vivo induction of DNA damage and senescence
BrdU speeds up hair follicle aging and reduces hair quality.
research Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy
This study found that eliminating senescent cells using senolytic drugs effectively prevented and reversed paclitaxel-induced peripheral neuropathy in mice.
research 1349 Inducing fate changes at the hair follicle stem cell nice
In this study, using a mouse model, researchers found that inducing senescence in hair follicle stem cells led to hair regeneration failure and sebaceous gland enlargement, akin to androgenetic alopecia features.
research Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects
In this review, researchers detail how immunosenescence and chronic neuroinflammation contribute to Parkinson's disease progression, exploring potential therapeutic strategies targeting this axis, such as senolytic agents and immune rejuvenation, while highlighting associated challenges and future research needs.
research Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy
In this study, DMC selectively eliminated senescent cells in old mice, prevented hair loss, improved motor coordination, and reduced senescence-associated secretory factors, suggesting its potential as a senolytic treatment.
research Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models
In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.
research The emerging role of cellular senescence in amyotrophic lateral sclerosis
This review discusses cellular senescence in relation to ALS and explores how targeting senescent cells could potentially serve as a treatment strategy, but it reports no new clinical findings and emphasizes that this link is not yet conclusively established.
research Integrating stem cell biology and organoid technology for skin regenerative therapies
This study reviews the role of skin stem cells in aging and explores how organoids, as opposed to traditional methods, can advance research into aging skin and regenerative therapies.
research From causes of aging to death from COVID-19
This review discusses the hyperfunction theory of aging as a key factor in COVID-19 vulnerability, highlighting the potential of anti-aging interventions like rapamycin to reduce this risk.
research Aromatic plants as cosmeceuticals: benefits and applications for skin health
This review highlights the potential of aromatic plants as natural antioxidants in cosmeceuticals, which may combat skin aging and promote rejuvenation by counteracting oxidative stress, offering a natural alternative to synthetic products with benefits like photoprotection and anti-wrinkle effects.
research Signalling by senescent melanocytes hyperactivates hair growth
In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.
research An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging
This study demonstrated that a new non-invasive method for collecting and analyzing mouse hair follicles could replace traditional biopsy methods, providing advantages for translational research and routine applications.