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    Glossary Senolytics

    Senolytics are a class of drugs or compounds that selectively induce apoptosis in senescent cells, which are cells that have stopped dividing and contribute to aging and age-related diseases. In the context of hair loss, senescent cells can accumulate in hair follicles, potentially disrupting normal hair cycling and contributing to conditions like androgenetic alopecia. By targeting these cells, senolytics may help rejuvenate hair follicles and promote healthier hair growth, making them a promising area of research in hair biology and regenerative medicine. Key distinguishing characteristics of senolytics include their ability to specifically eliminate senescent cells without affecting healthy, proliferating cells.

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    Research 30 of 92

    1. 471 Senolytic Potential of Fisetin and ABT Compounds in Dermal Fibroblasts Journal of Investigative Dermatology · 2025
    2. Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts Aging · 2018 · 133 citations
    3. Wound healing: cellular mechanisms and pathological outcomes Open Biology · 2020 · 1425 citations
    4. Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents Aging Cell · 2023 · 48 citations
    5. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    6. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    7. Frontiers in Topical Photoprotection Cosmetics · 2025 · 6 citations
    8. Cellular Senescence and Aging in Myotonic Dystrophy International Journal of Molecular Sciences · 2022 · 4 citations
    9. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    10. Platelet Immune Interactions, Lifespan, and Senescence OBM Geriatrics · 2025 · 1 citations
    11. A review on skin aging: mechanisms and therapeutic strategies Journal of Applied Pharmaceutical Research · 2026
    12. A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies Pharmaceutics · 2025
    13. Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging Aging Cell · 2025
    14. Restoration of hair follicle inductive properties by depletion of senescent cells Aging Cell · 2024
    15. 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons Journal of Investigative Dermatology · 2024
    16. 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs Journal of Investigative Dermatology · 2024
    17. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives Journal of Investigative Dermatology · 2022
    18. 0950 Exploring hair aging through ex vivo induction of DNA damage and senescence Journal of Investigative Dermatology · 2025
    19. Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy Cancer Research · 2024
    20. 1349 Inducing fate changes at the hair follicle stem cell nice Journal of Investigative Dermatology · 2023
    21. The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle Trends in Cell Biology · 2018 · 68 citations
    22. Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects Frontiers in Immunology · 2026
    23. Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy Redox biology · 2023
    24. Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models Pharmaceutics · 2025
    25. The emerging role of cellular senescence in amyotrophic lateral sclerosis Frontiers in Neuroscience · 2025 · 1 citations
    26. Integrating stem cell biology and organoid technology for skin regenerative therapies Health engineering. · 2025
    27. Aromatic plants as cosmeceuticals: benefits and applications for skin health Planta · 2024 · 22 citations
    28. Signalling by senescent melanocytes hyperactivates hair growth Nature · 2023 · 27 citations
    29. An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging Aging · 2021 · 12 citations
    30. Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review International Journal of Nanomedicine · 2025 · 4 citations