330 citations
,
December 2009 in “Cell stem cell” This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.
143 citations
,
September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
91 citations
,
March 2011 in “Stem Cell Reviews and Reports” This article describes protocols for isolating and expanding human epidermal neural crest stem cells and discusses their potential for cell-based therapies in regenerative medicine, but reports no new clinical results.
91 citations
,
December 2006 in “Proceedings of the National Academy of Sciences” In this study, researchers found that hair follicle orientation in Fz6 −/− mice is disrupted and that hair may reorient itself over time through a self-organized process.
68 citations
,
March 2019 in “Advanced Healthcare Materials” This review assesses the benefits and limitations of various supramolecular hydrogels, including polymeric and peptide-based types, for wound healing, but reports no new clinical results.
48 citations
,
July 2002 in “Journal of Cutaneous Medicine and Surgery” This review discusses the variety of skin conditions linked to eating disorders and emphasizes that resolving these skin issues often requires treating the underlying disorder.
45 citations
,
November 2017 in “Biomaterials” This study demonstrated a method for large-scale preparation of self-sorted hair follicle germs in vitro, which successfully generated hair follicles when transplanted into the skin of nude mice.
36 citations
,
September 2019 in “Journal of Herbal Medicine” This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.
33 citations
,
December 2012 in “NMR in Biomedicine” This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.
32 citations
,
October 1999 in “Journal of women's health and gender-based medicine” This study found that women with androgenetic alopecia report various negative impacts on their lives due to hair thinning, highlighting emotional concerns and dissatisfaction with appearance.
31 citations
,
May 2015 in “Stem Cell Reports” This research discusses a novel imaging approach in live mice to study stem cell and niche interactions in tissue homeostasis and reports no new results.
31 citations
,
November 2000 in “Journal of the European Academy of Dermatology and Venereology” This article discusses the diverse dermatological symptoms associated with sexual abuse, highlighting the challenges in establishing causal links and the potential long-term psychosomatic manifestations, without reporting new research results.
27 citations
,
March 2013 in “Social Semiotics” This study analyzes how commercial websites for Propecia depict male hair loss and promote medical treatment, suggesting they contribute to medicalizing a natural condition for profit.
23 citations
,
March 2023 in “eLife” This study reveals that epidermal stem cell differentiation in mice involves dynamic transcriptional changes, with Keratin-10 transcription preceding gradual chromatin compaction shifts associated with differentiation.
20 citations
,
January 2015 in “Polish Journal of Pathology” Reflectance confocal microscopy is a useful, non-invasive tool for diagnosing some skin diseases, with potential for future improvements.
16 citations
,
February 2014 in “Journal of Investigative Dermatology” This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.
14 citations
,
June 2023 in “Journal of Infection and Public Health” This study observed a low rate of long-COVID lasting more than three months among mostly vaccinated healthcare workers during the Omicron wave, suggesting that further research is needed to assess the impact of different vaccines on long-COVID-19 in this group.
12 citations
,
November 2014 in “PLOS Computational Biology” In this study, researchers found that synchronization between expanding epithelial cells and background mesenchymal cells in the mouse hair cycle may be maintained by inhibitory regulation, with potential mediators of this regulation identified.
12 citations
,
September 2013 in “BMC Biophysics” This study developed a model showing that keratin elasticity in skin may be influenced by electrostatic and bridging interactions between keratin filaments, contingent on the balance of charges in the surrounding medium.
10 citations
,
November 2023 in “Frontiers in Pharmacology” In this study, researchers developed a self-assembling hydrogel called RADA-PDGF2 and found it to accelerate wound closure in a mouse model due to its pro-proliferative and pro-migratory properties, without causing cytotoxicity or immunogenicity.
10 citations
,
January 2019 in “in Vivo” In this study, finasteride was found to enhance stem cell properties in dermal papilla cells, suggesting potential benefits for hair loss management and regenerative therapies.
10 citations
,
November 2015 in “American Journal of Primatology” This study found that rhesus macaques with inhibited or anxious temperaments had less alopecia, suggesting temperament may influence hair loss in these animals.
9 citations
,
December 2024 in “Nano Research” In a study on diabetic mice, researchers developed a protein-based hydrogel that leverages zinc ions and the natural compound phellopterin to promote cutaneous nerve regeneration, angiogenesis, and tissue remodeling in diabetic wounds, highlighting its potential for advanced wound therapy.
9 citations
,
August 2019 in “Lupus” This study found that body image-related quality of life significantly mediates the relationship between pain and depressive symptoms in patients with systemic lupus erythematosus.
5 citations
,
January 2025 in “BMC Medical Informatics and Decision Making” This review examines the use of computer vision techniques, specifically deep learning architectures and image processing algorithms, for detecting and assessing skin conditions like vitiligo and dermatitis, and highlights the need for disease-specific datasets to improve automated diagnostic tools in dermatology.
5 citations
,
September 2017 in “Colloids and surfaces. B, Biointerfaces” This study found that treating hair with 1 M sodium hydroxide increases its self-friction coefficient, suggesting potential applications in forming fine frictional fibers for medical uses.
4 citations
,
September 2016 in “Journal der Deutschen Dermatologischen Gesellschaft” This study found that 7.9% of dermatological outpatients at a German hospital had clinically relevant body dysmorphic concerns, highlighting the need for psychotherapeutic support due to poor social adaptation and high motivation for change.
4 citations
,
October 2012 in “Expert Review of Dermatology” Dermoscopy greatly improves melanoma diagnosis and reduces unneeded surgeries.
3 citations
,
August 2022 in “Pharmaceuticals” This study observed that a self-emulsifying drug delivery system for finasteride significantly enhanced bioavailability in rats compared to commercial tablets, but the formulation was found to be thermodynamically unstable.
2 citations
,
November 2015 in “Actas Dermo-Sifiliográficas” This review discusses the characteristics and potential applications of epidermal stem cells in dermatology, without providing new clinical results.