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The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

PDCD4 is important for controlling skin cell growth and healing.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

Sox2 controls hair color by affecting pigment production in hair follicles.

CD4+ skin cells may be precursors to basal cell carcinoma.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

Gray hair can potentially be reversed, leading to new treatments.

Lactate production is important for activating hair growth stem cells.

The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.

Intermittent fasting slows hair growth by damaging hair follicle cells.

Endoglin is crucial for proper hair growth cycles and stem cell activation in mice.

CIP/KIP proteins help stop cell division and support hair growth.

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Androgens prevent hair growth by changing Wnt signals in cells.

Using a fractional laser can stimulate hair growth, but the intensity and duration of inflammation are crucial. Too much can cause ulcers and scarring. Lower beam energy and fewer treatments are recommended to avoid damage.

New effective scar treatments are urgently needed due to the current options' limited success.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

The new microwell device helps grow more hair stem cells that can regenerate hair.

BMP6 and Wnt10b control whether hair follicles are resting or growing.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.