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This review highlights significant research trends and challenges in utilizing plant-derived extracellular vesicles for drug delivery and biomedical applications, emphasizing the need for standardized protocols and advanced purification technologies.

Spironolactone is effective for treating female hair loss, with new treatments like clascoterone showing promise.

This narrative review highlights that declining testosterone levels are a complex public health issue potentially influenced by modifiable lifestyle factors and environmental stressors, suggesting integrated strategies may be needed to address the trend's impacts on health.

This study evaluated a new composite material made from PLA, ALG, ZnS, and HT for blood-contacting applications, finding it improved surface characteristics and displayed anticoagulant properties and high biocompatibility with no genotoxic effects on blood and skin cells.

This book chapter discusses the mechanisms and prevention of selenium toxicity in livestock and reports no new experimental results; it emphasizes reducing selenium in the human food chain through animal products.

This review discusses the potential link between selenium supplementation and symptoms of chronic selenium toxicity, such as hair loss and nail dystrophy, due to excess intake leading to disruptions in hair and nail protein structure.

This consensus paper reviews expert opinions on treating telogen effluvium but reports no new clinical findings.

This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.

This study reviewed different hair loss treatments and suggested that microneedling, PRP therapy, hair transplantation, and certain pharmacological and supplementation approaches show varying effectiveness, with some needing further research for confirmation.

This study found that small amounts of subcutaneously injected Se75 were deposited and retained in the hair of dogs for up to 316 days.

This study identified chronic selenosis in horses in western Iowa due to elevated selenium intake from locally produced alfalfa hay, leading to symptoms like alopecia and hoof deformities.

Selenium levels in soil, crops, and human hair in Northwest China are within safe limits.

In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.

This chapter reviews hormonal imbalances and related disorders, discussing nutraceuticals—such as cod liver oil, green tea, and Omega-3s—that may alleviate symptoms and improve hormonal fluxes in lieu of traditional synthetic treatments that have potential side effects.

This narrative review describes the components of human hair and their nutritional importance but reports no clinical results; the authors suggest dietary sulfur amino acids are essential for hair health.

This review discusses various prostate cancer prevention strategies and reports no new clinical results; the authors highlight the need for ongoing research in this area.

This narrative review highlights the crucial role of micronutrients and gut microbiota in thyroid function and suggests that nutritional imbalances may contribute to thyroid dysfunction or diseases.

This review investigates how selenium, a trace element found in wheat, may impact hair health by examining its biochemical role in hair follicle biology and its potential therapeutic and toxicological effects.

This case report found that two women developed toxic selenium levels after consuming paradise nuts, resulting in symptoms like massive hair loss and nail discoloration.

In this randomized trial, lupus patients taking daily 200 μg selenium supplements for eight weeks showed significant improvements in metabolic markers like CRP, ESR, MDA, and GPX, as well as reduced clinical symptoms such as arthritis and alopecia, compared to those receiving a placebo.

In this study, the Selenium-Chitosan-Mupirocin nanohybrid system significantly enhanced wound healing in a rat model of diabetic wound infection compared to the control, suggesting potential for treating mild diabetic wounds.

This review outlines the current state of freeze-dried platelet-rich plasma (FD-PRP) research, emphasizing its use in wound healing, lumbar fusion, knee conditions, and dentistry, but reports no new clinical findings.

This study found that the ethyl acetate fraction of Hibiscus rosa sinensis petals significantly reduced serum glucose and glycated hemoglobin levels in diabetic rats, with effects comparable to metformin.

Some nutrients and antioxidants may improve skin and hair health, but more research is needed to confirm these benefits.

This study identified dose levels of selenium that can produce toxicity, noting that doses as low as 2-3 µg Se/kg bw/day can lead to adverse effects, and a human mortality study linked 300 µg/day consumption to increased death risk.

Accidental findings have led to new hair treatment discoveries, like using blood pressure and diabetes medications for hair loss and unwanted hair.

In this preliminary study, selenium-resistant bacteria and selenium-treated pea sprout extracts showed minimal inhibitory effects on the dandruff-associated fungus Malassezia furfur compared to controls, suggesting potential for further investigation.

In this study, women with acute telogen effluvium taking the Hair’InsideTM supplement for 84 days showed significant improvements in hair regrowth, shedding, brightness, and volume compared to placebo, with no reported adverse effects.

This abstract introduces dandruff as a key obstacle to achieving beautiful hair and a healthy scalp, noting its impact on appearance and self-confidence, but it does not provide study results.

This review establishes a tolerable upper intake level of 255 μg/day for selenium in adults, warning that supplements and Brazil nuts may cause excess intake.