5 citations
,
January 2004 in “Biochimie” This review discusses arsenic trioxide therapy in acute promyelocytic leukemia and introduces a novel method using hair analysis to monitor arsenic exposure and correlate it with treatment timing, but reports no new clinical results.
35 citations
,
May 2008 in “Journal of Clinical Oncology” A cancer patient died from a severe skin reaction after taking the drug cetuximab.
49 citations
,
November 1984 in “JAMA” This case report describes a 61-year-old woman with Sjögren's syndrome who experienced multiple episodes of aseptic meningitis linked to trimethoprim-sulfamethoxazole and trimethoprim use.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
September 2020 in “Nature, Environment and Pollution Technology/Nature, environment and pollution technology” This study found that Wistar rats fed with grass extracts from mining areas accumulated trace metals, particularly in the spleen, leading to organ pathology and signs of toxicity.
5 citations
,
March 1992 in “PubMed” In this study, researchers found that arsenic transfer to induced hair in rats increased sharply at first and then more gradually, correlating significantly with arsenic levels in key organs.
32 citations
,
March 1948 in “The journal of investigative dermatology/Journal of investigative dermatology”
March 2002 in “Clin-Alert” In 2002, various drugs caused serious side effects, including vitamin B12 deficiency, heart issues, blindness, hypersexuality, allergic reactions, blood clotting problems, pupil dilation, capillary leak syndrome, muscle breakdown, hepatitis, skin reactions, and lupus.
This study found that while many Saudi individuals use vitamin D supplements, vitamin D toxicity was reported by a small percentage, indicating the need for further research on contributing factors.
May 1985 in “The Pediatric Infectious Disease Journal” This report describes a case of a patient with Sjogren's syndrome who experienced multiple episodes of aseptic meningitis linked to taking trimethoprim-sulfamethoxazole and trimethoprim alone.
November 2023 in “IntechOpen eBooks” This source highlights that arsenic exposure through contaminated groundwater is a significant global health risk, leading to skin and hair conditions such as pigmentation changes, skin irritation, alopecia, and can eventually result in skin cancer.
21 citations
,
August 1987 in “Archives of Dermatology” This communication reports previously unreported side effects, severe bullous dermatosis and onycholysis, in three patients undergoing high-dose methotrexate and leucovorin calcium therapy, impacting their chemotherapy schedules.
1 citations
,
January 2007 in “The Kitakanto Medical Journal” This report documents a case where a man survived sub-acute toxicity from an overdose of the anticancer drug UFT due to effective treatment with antibiotics and granulocyte colony-stimulating factor.
February 2004 in “Frontiers in Ecology and the Environment” This article discusses Dr. Jane Hightower's findings on mercury poisoning linked to fish consumption in patients and reports no new clinical results; it highlights ongoing debate and regulatory actions.
January 2021 in “Universal Journal of Pharmaceutical Research” This study found that methanol extract of Russelia equisetiformis reduced liver damage from paracetamol overdose in rats, suggesting it has a protective effect against hepatic injury.
13 citations
,
March 1999 in “Biochemical Journal” In this study, transgenic mice overexpressing the SSAT gene were highly sensitive to polyamine analogues, leading to severe liver changes and high mortality rates after treatment.
September 2023 in “Translational medicine reports” This case study reported that an 18-year-old woman ingested a large amount of topical minoxidil, leading to symptoms like low blood pressure, increased heart rate, and elevated liver enzymes, but recovered fully after treatment. Minoxidil toxicity may rarely cause abnormal liver enzyme levels.
5 citations
,
January 2021 in “Indian Journal of Critical Care Medicine” This case report details severe hematological toxicity and fatal complications from azathioprine in a patient with Crohn's disease with a homozygous NUDT 15 variant, suggesting pharmacogenomic testing before treatment.
October 2025 in “The Sri Lanka Journal of Dermatology” This report describes two cases of toxic epidermal necrolysis with long-term mucosal scarring and liver issues, underscoring the complexities of recovery and chronic effects of this severe drug reaction.
114 citations
,
March 2002 in “Current opinion in oncology/Current opinion in oncology, with cancerlit” This review discusses various skin side effects from chemotherapy, noting that they are mainly toxic rather than allergic and often include alopecia, which can cause significant distress to patients.
54 citations
,
February 2002 in “Carcinogenesis” This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.
6 citations
,
December 2022 in “Toxicological Research”
January 1992 in “Side effects of drugs annual” Some people have severe allergic reactions to anthelminthic drugs, but these are often due to the parasites, not the drugs.
This study found that tenuazonic acid from Alternaria alternata can cause significant damage to vital organs in mice at low doses and highlights the need for regulatory measures to manage its risk in agricultural products.
4 citations
,
March 2020 in “JAAD Case Reports” This case report describes a 47-year-old male with rare total melanonychia linked to vitamin B12 deficiency, whose nail discoloration and constitutional symptoms improved following vitamin B12 supplementation.
5 citations
,
October 2001 in “British Journal of Ophthalmology” This abstract describes the initial success of intralesional cidofovir for SCC treatment and states that it has not shown systemic toxicity, but it does not report new clinical trial results.
January 1988 in “Toxicological Sciences” In this study, a single oral dose of 2,3,4,7,8-pentachlorodibenzofuran in male Fischer rats led to dose-dependent toxicity, resulting in weight loss, hepatotoxicity, and mortality.
March 2025 in “International Journal of Trichology” This case report describes a 38-year-old woman who experienced significant hair loss known as anagen effluvium after accidentally ingesting Gloriosa superba tubers, a plant commonly found in tropical regions with high colchicine content.
19 citations
,
June 2011 in “British Journal of Dermatology” Severe digestive issues in DRESS need early endoscopy for better treatment.
January 1994 in “Toxicological Sciences” This study found that chronic high dosages of 2-(difluoromethyl)-dl-ornithine caused various toxicities in rats and dogs, with some effects potentially minimized at lower dosages.