23 citations
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October 1995 in “PubMed” This case report identifies alopecia universalis in a worker as a result of occupational selenium intoxication.
This study found that ingesting seeds from the Lecythis ollaria tree may cause hair loss and other toxic effects in animals.
78 citations
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December 2011 in “Clinical toxicology” This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.
36 citations
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January 2010 in “Human & experimental toxicology” This case report found that two women developed toxic selenium levels after consuming paradise nuts, resulting in symptoms like massive hair loss and nail discoloration.
7 citations
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January 1995 in “Journal American Society of Mining and Reclamation” This review discusses the forms of selenium and sulfur in soil, their plant absorption, and risks of toxicity to livestock, emphasizing selenium's role in selenosis and sulfur's link to polioencephalomalacia in ruminants; it reports no new experimental results.
This book chapter discusses the mechanisms and prevention of selenium toxicity in livestock and reports no new experimental results; it emphasizes reducing selenium in the human food chain through animal products.
10 citations
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April 2019 in “Environmental Science and Pollution Research” In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits.
6 citations
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March 2011 in “Experimental Dermatology” This study found that an imbalance of selenium in a C57BL/6 mouse model led to hair loss with color change and was linked with changes in hair follicle apoptosis markers.
11 citations
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January 1993 in “Journal of Veterinary Diagnostic Investigation” This study identified chronic selenosis in horses in western Iowa due to elevated selenium intake from locally produced alfalfa hay, leading to symptoms like alopecia and hoof deformities.
27 citations
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June 2010 in “Journal of the American Academy of Dermatology” Excessive selenium in supplements can cause hair loss and nail issues.
382 citations
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February 2010 in “Archives of Internal Medicine” This study identified that high concentrations of selenium in a liquid dietary supplement caused a widespread outbreak of poisoning, revealing the importance of stricter manufacturing standards.
7 citations
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August 2025 in “Plants” This review highlights the role of plant-derived organic selenium compounds, noting their high bioavailability and low toxicity, and provides a comprehensive overview of selenium's uptake in plants and metabolism in humans, offering a theoretical basis for future nutritional research.
1 citations
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December 2019 This documentation reviews the absorption, metabolism, and excretion of selenium and its compounds, highlighting the complex interactions and health implications, but reports no new clinical results.
January 2019 in “Springer eBooks” This review discusses drugs and mechanisms possibly responsible for chemical- and drug-induced hair loss but presents no new research findings.
12 citations
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June 2023 in “Journal of trace elements in medicine and biology” This study identified dose levels of selenium that can produce toxicity, noting that doses as low as 2-3 µg Se/kg bw/day can lead to adverse effects, and a human mortality study linked 300 µg/day consumption to increased death risk.
76 citations
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April 2002 in “Urology” This review examines the use of selenium and vitamin E supplements for reducing prostate cancer risk, finding mixed evidence that suggests benefits may be limited to individuals with specific risk factors, like low baseline levels or smoking history, rather than broadly applicable.
70 citations
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June 2010 in “Clinics in Dermatology” This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.
May 2026 in “The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy” The researchers reported that integrating the naturopathic complex Detoxil into standard therapy for chronic dermatoses enhances detoxification, normalizes metabolic markers, and accelerates symptom resolution, suggesting potential benefits for managing skin conditions.
3 citations
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April 2023 in “Journal of Veterinary Internal Medicine” This study found that dogs with idiopathic epilepsy had altered hair concentrations of several trace elements, which may suggest a role in the disease's pathophysiology and indicate effects from antiseizure medications.
26 citations
,
January 2018 in “Skin appendage disorders” This review summarizes existing studies on toxic agents that can cause alopecia, with thallium and colchicine having the most established links, while others like botulinum toxin A need further investigation.
7 citations
,
October 2020 in “Dermatology practical & conceptual” This review discusses the potential risks associated with skin, hair, and nail supplements, highlighting concerns about safety, efficacy, and lack of regulation but reports no new clinical results.
This study highlights the increasing association between popular diets, unregulated supplements, and various skin disorders, emphasizing the need for clinicians to thoroughly assess dietary histories to manage nutrition-related skin issues effectively.
12 citations
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January 2007 in “Current problems in dermatology” This review discusses the impact of various exogenous agents on hair, such as cosmetics and radiation, but reports no new experimental results.
324 citations
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July 2020 in “Applied Water Science” This study found high levels of toxic heavy metals in water sources of mining communities in Abakaliki, Nigeria, posing potential health risks including Parkinson's and Alzheimer's diseases.
98 citations
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October 2012 in “Dermatologic Clinics” This article reviews the impact of nutritional deficiencies on hair health, detailing how they can cause structural abnormalities, pigmentation changes, or hair loss; it presents no new clinical findings.
5 citations
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January 2022 in “Proceedings of the Pakistan Academy of Sciences B Life and Environmental Sciences” This review discusses the role of nanoparticles in cancer diagnosis and treatment and outlines their potential to improve outcomes by reducing systemic toxicity and overcoming multidrug resistance, though it reports no new clinical results.
5 citations
,
December 2005 in “Clinical Techniques in Equine Practice” This review discusses how skin lesions and haircoat changes in adult horses can indicate systemic diseases, emphasizing the need for veterinary evaluation, and reports no new clinical findings.
1 citations
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January 2010 in “Springer eBooks” Certain micronutrients may improve hair and nail health, but more research is needed to confirm their benefits.
January 2022 in “European Proceedings of Life Sciences” This article discusses the genetic polymorphisms affecting the antioxidant system and suggests that personalized detoxification plans and nutrition may be beneficial for patients with chronic diseases, but it reports no new clinical findings.
96 citations
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September 2017 in “Analytica Chimica Acta” This review discusses the growing use of scalp hair for elemental analysis in various fields and highlights advancements in analysis techniques, including the future potential of laser ablation ICP-MS, but reports no new clinical results.