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No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

New treatments for advanced skin cancer are improving patient outcomes, but drug resistance and finding the right treatment combinations are still big challenges.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

Targeting colon cancer stem cells might lead to better treatment results.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

EGF controls hair growth by regulating hair follicles' growth phases.

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.

Sebocytes play a key role in controlling androgen levels in human skin.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.

Finasteride effectively treats male hair loss, improving growth and density.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Setipiprant may reduce inflammation by blocking an enzyme called aldose reductase.

Abemaciclib can cause skin, hair, and nail problems, leading some patients to stop using it.