149 citations
,
July 2002 in “Dermatologic clinics” This review discusses the pathogenesis, clinical presentation, diagnosis, and treatment of cutaneous lupus erythematosus, reporting no new clinical findings.
140 citations
,
February 2020 in “Frontiers in Plant Science” This article discusses the potential of RNA-based biopesticides for sustainable agriculture and reports no new experimental results; it highlights the need for improved delivery systems and regulatory development to enhance deployment.
139 citations
,
December 2020 in “Cell Stem Cell” Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
138 citations
,
June 2019 in “Stem Cells and Development” This review explores the potential of periodontal ligament stem cells for regenerative therapy in periodontium, despite challenges due to their rarity, and reports no clinical results.
131 citations
,
September 2010 in “The Laryngoscope” This study found that forehead feminization significantly contributes to recognizing female gender and reported that feminizing forehead cranioplasty is a safe procedure with a low complication rate.
130 citations
,
February 2018 in “Journal of Investigative Dermatology” This study found that tofacitinib led to ≥50% hair regrowth in eight out of twelve patients with moderate to severe alopecia areata, suggesting a potential benefit for using JAK inhibitors in treating this condition.
120 citations
,
June 2008 in “American Journal of Epidemiology” This study reported a 6.3% prevalence of PCOS among women in a Sri Lankan community, with most cases presenting as oligo/amenorrhea and polycystic ovaries.
120 citations
,
July 2005 in “Dermatologic surgery” This study found that topical niacinamide significantly improved the appearance of wrinkles, skin yellowing, and elasticity in aging facial skin over 12 weeks.
117 citations
,
November 2006 in “Experimental Dermatology” This review explores the biology of wool follicles and suggests their potential use as research models in modern biology, but it reports no new findings.
116 citations
,
May 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study discovered that the circadian clock influences hair follicle regeneration, making hair grow faster in the morning and causing more radiation-induced hair loss in the morning compared to the evening.
114 citations
,
January 2014 in “World Journal of Gastroenterology” This study highlights the potential increased frequency of advanced liver disease in obese PCOS patients with NAFLD and underscores the importance of lifestyle modifications as initial treatment.
114 citations
,
April 2004 in “International Journal of Dermatology” Postinflammatory hyperpigmentation causes dark skin patches and needs personalized treatment.
110 citations
,
July 2017 in “Immunology” This review discusses the role of regulatory T cells in skin, including their impact on hair follicle regeneration, wound healing, and immune tolerance, without presenting new clinical findings.
109 citations
,
March 2011 in “Journal of controlled release” This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.
109 citations
,
January 2011 in “Frontiers in Systems Neuroscience” The researchers reported that differences in brain functional connectivity between unmedicated seasonal affective disorder patients and healthy controls vary with ICA model order, peaking in volume at model order 70.
105 citations
,
August 2010 in “Pharmacology & therapeutics” This article explores the potential of formyl-peptide receptor 2 agonists as innovative anti-inflammatory drugs, highlighting their ability to mimic the body's natural inflammation response, but it presents no new clinical findings.
102 citations
,
October 1996 in “Dermatologic Clinics” Photographic documentation crucial for evaluating hair growth in androgenetic alopecia.
101 citations
,
October 2013 in “Journal of The Saudi Pharmaceutical Society” This study found that the nanostructured lipid carrier gel containing minoxidil showed good consistency and a prolonged drug release in vitro, suggesting potential for treating alopecia.
100 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.
99 citations
,
July 2017 in “Clinical Reviews in Allergy & Immunology” This review noted that alopecia areata is an autoimmune disease impacting hair follicles and offered insights into its complex pathogenesis involving immune responses, while highlighting ongoing research into new treatments such as Janus kinase inhibitors and other immunomodulatory drugs.
97 citations
,
December 2010 in “Journal of Neuroscience” This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.
90 citations
,
March 2017 in “JAMA Internal Medicine” In this study, older men using 5α-reductase inhibitors for prostatic enlargement did not show increased risk of suicide, but had elevated risks of self-harm and depression.
88 citations
,
July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
87 citations
,
August 2017 in “Scientific Reports” This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.
86 citations
,
January 2019 in “Frontiers in Immunology” The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.
86 citations
,
June 2017 in “Stem cell investigation” This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.
86 citations
,
May 2011 in “Journal of The American Academy of Dermatology” This study found that patients with alopecia perceive their hair loss as more severe than dermatologists do, and their own ratings of hair loss severity better reflect their quality of life impacts.
85 citations
,
June 2015 in “Scientific Reports” This study applied semantic text-mining to identify phenotypes linked to over 6,000 diseases, demonstrating that these phenotypes can accurately identify known disease-associated genes, creating a human disease network based on phenotypic similarity.
85 citations
,
October 2006 in “Current opinion in cell biology” This article reviews advances in feather development and regeneration, including pattern formation, stem cell biology, and evolution, but presents no new experimental results.
83 citations
,
June 2018 in “Frontiers in immunology” This review discusses the roles of αβ and γδ T cells in skin health and disease and reports no new clinical results; the authors highlight potential therapeutic developments.