24 citations
,
February 2007 in “Hormone and metabolic research” This study suggests that inhibiting 5α-reductase activity alone, particularly with the type 1 inhibitor MK386, may not effectively reduce sebocyte activity or improve acne.
23 citations
,
April 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the classification and diagnosis of primary cicatricial alopecias and reports no new clinical results; it highlights the need for effective treatments owing to limited evidence of current therapies' efficacy.
23 citations
,
March 2001 in “Clinics in Dermatology” This article reviews treatment options for male androgenetic alopecia, including minoxidil, 5 alpha reductase inhibitors, and hair transplantation, but reports no new clinical findings.
23 citations
,
March 1994 in “Fertility and sterility” This study found that oral contraceptives effectively suppressed hyperandrogenemia in most patients with hyperandrogenic-insulin-resistant acanthosis nigricans syndrome, though GnRH-a therapy was beneficial for those not responding initially.
23 citations
,
April 1991 in “Journal of The American Academy of Dermatology” Minoxidil solution can cause skin irritation and allergies in some users.
22 citations
,
March 2019 in “The Journal of Cell Biology” This study identified that the Wave complex proteins ABI1 and Wave2 play a crucial role in regulating epidermal shape and growth during skin development, notably influencing SOX9 expression and Wnt signaling pathways.
21 citations
,
July 2010 in “International Journal of Cosmetic Science” This study found that hair luster decreases with age in Japanese females, primarily due to an irregular increase in fiber curvature which affects hair alignment.
21 citations
,
January 2000 in “Fetal Diagnosis and Therapy” This study found that trichothiodystrophy can be diagnosed prenatally in the second trimester using an endoscopically-guided fetal eyebrow biopsy, with sulfur content analysis being the most reliable test.
20 citations
,
January 2012 in “Journal of Steroids & Hormonal Science” The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.
20 citations
,
August 1997 in “PubMed” This study indicates that activating K+ channels in dermal papilla cells alone may not promote hair growth, despite some openers being effective on certain channels.
19 citations
,
March 2020 in “Mayo Clinic Proceedings” Breast pain is common and usually not linked to cancer, with treatment varying by severity.
19 citations
,
February 2007 in “International Clinical Psychopharmacology” This study provided the first published case reports of alopecia associated with the use of quetiapine.
19 citations
,
March 2003 in “Journal of Investigative Dermatology” This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.
18 citations
,
May 2014 in “Menopause” This study found that a 5-mg daily dose of transdermal testosterone cream in postmenopausal women restored testosterone levels to those typical of premenopausal women.
18 citations
,
January 1990 in “Journal of The American Academy of Dermatology” This study found that dexamethasone effectively suppressed DHEAS levels in women with elevated levels using much lower doses than previously thought, without significant adverse effects.
17 citations
,
June 2018 in “Frontiers in Physiology” This study found that acellular dermal matrix scaffolds may facilitate full-thickness skin wound healing by promoting a pro-regenerative immune response through M2 macrophage polarization via the Lamtor1 pathway.
16 citations
,
March 2022 in “Journal of Infection” This study observed that sera from Covaxin-vaccinated individuals showed reduced neutralization ability against the Omicron variant compared to B.1, Beta, and Delta variants, with breakthrough infections boosting immune response more effectively than vaccination alone.
16 citations
,
January 2011 in “International Journal of Trichology” This article discusses the principles and considerations of clinical photography for hair disorders in dermatology, reporting no new clinical findings.
16 citations
,
October 2007 in “Andrologia” This study suggests that DHT may have a less potent effect on the prostate compared to testosterone while maintaining safety and similar effects on erythropoiesis and lipids.
16 citations
,
October 2004 in “Journal of Investigative Dermatology” This study found that normal human melanocytes can be protected from apoptosis through both PI 3-kinase/Akt-dependent and independent pathways, with insulin and TPA offering nearly complete protection.
15 citations
,
November 2017 in “Drug Delivery and Translational Research” This study found that co-applying Curcuma aeruginosa extract or essential oil with minoxidil significantly increased minoxidil's skin penetration in an ex vivo setting, suggesting an improved topical treatment strategy for androgenic alopecia with greater efficacy and the potential for lower minoxidil doses.
14 citations
,
March 2007 in “Pediatric pulmonology” This study found evidence suggesting that hypertrichosis may be an adverse effect of inhaled corticosteroids in children, although it does not always resolve after stopping treatment.
14 citations
,
May 2004 in “Annals of Plastic Surgery” This study found that muscle-only free flaps for skull coverage were associated with serious complications, suggesting that composite or thicker muscle flaps may reduce these risks.
13 citations
,
September 2020 in “Dermatologic Therapy” This review discusses the use of microneedling for androgenetic alopecia and finds it promising for enhancing hair density and thickness, especially when combined with other treatments, but notes no standardized protocol exists yet.
13 citations
,
January 2013 in “Applied and Environmental Microbiology” This study found that regio-specific hydroxylation of cyclosporine A in Sebekia benihana is mediated by the cytochrome P450 hydroxylase CYP-sb21, suggesting potential biotechnological applications for hair growth promotion without immunosuppressive effects.
13 citations
,
December 2006 in “Journal of experimental animal science” This study found that injecting interferon gamma into C3H/HeJ mice did not alter the frequency or onset of alopecia areata, suggesting the protein alone does not trigger the disease.
13 citations
,
September 1976 in “Archives of Environmental Health An International Journal” In this study, Bushman women in various life stages had higher levels of iron and zinc in their hair compared to Bantu and American mothers, with iron deficiency anemia being rare among them.
11 citations
,
November 2022 in “Journal of Endocrinological Investigation” In this study, gender-affirming hormonal treatment was associated with increased hair growth, acne, and alopecia prevalence in transgender individuals assigned female at birth, while opposite dermatological changes were observed in those assigned male at birth.
10 citations
,
September 2018 in “Regenerative Medicine” This review explores the mechanism and potential applications of wound-induced hair follicle neogenesis but reports no new clinical results, highlighting the need for further research in hair regeneration therapies.
10 citations
,
October 2017 in “BMJ Open” This article outlines the first prospective cohort study examining whether bariatric surgery can induce satisfactory weight loss in obese Koreans, with no new results reported yet.