296 citations
,
October 2018 in “General and Comparative Endocrinology” This review discusses the use of hair cortisol concentration as a marker for chronic stress and long-term cortisol secretion in animals, highlighting its benefits and the need for standardized sampling protocols.
93 citations
,
February 2015 in “Journal of Investigative Dermatology” This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.
49 citations
,
May 2018 in “Endocrine” This study found that only eumenorrheic polycystic ovary syndrome patients showed a temporal coupling between kisspeptin and luteinizing hormone pulsatile secretions.
45 citations
,
May 2019 in “Scientific Reports” This study reported that a low color temperature light (1900 K) may have positive effects on melatonin secretion, eye protection, wound healing, and hair regeneration compared to higher temperature lights.
42 citations
,
February 2018 in “International Journal of Molecular Sciences” This study suggests that minoxidil may enhance hair growth by stimulating adipose-derived stem cell motility and growth factor secretion, promoting dermal papilla cell proliferation and accelerating anagen induction.
41 citations
,
February 2012 in “Journal of Neuroendocrinology” This study suggests that in late pregnancy, allopregnanolone induces opioid inhibition of oxytocin secretion in response to immune challenge, potentially minimizing the risk of preterm labor in rats.
36 citations
,
January 2004 in “European journal of cell biology” This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.
29 citations
,
January 2021 in “Journal of Investigative Dermatology” This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.
21 citations
,
December 2023 in “Bioengineering & Translational Medicine” This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.
10 citations
,
January 2014 in “BioMed research international” In this study, dermal papilla cells from rat vibrissae showed potential for treating CNS injuries by secreting neurotrophic factors and promoting neuronal differentiation more effectively than bone marrow mesenchymal stem cells.
9 citations
,
April 2019 in “Biomolecules & Therapeutics” This study found that udenafil-treated adipose-derived stem cells accelerated hair growth in mice by enhancing stem cell activity and growth factor secretion through the ERK and NFκB pathways.
6 citations
,
July 2018 in “Steroids” This study found that testosterone significantly influenced the expression and function of certain ion transporters in the vas deferens, impacting fluid secretion and contributing to a suitable environment for male fertility.
5 citations
,
January 2021 in “BioMed Research International” This study found that a noncrosslinked hyaluronic acid filler restored cell viability against UVB-induced cytotoxicity and increased VEGF secretion in human dermal papilla cells, suggesting potential for mesotherapy use after further research.
3 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” In this study, Buserelin nasal spray significantly reduced hirsutism scores and suppressed ovarian steroid secretion in women with non-adrenal hirsutism over six months, with effects lasting post-treatment.
2 citations
,
May 2023 in “Frontiers in Pharmacology” This review article summarizes findings that suggest natural products may help treat skin inflammation related to abnormal hormone secretion by the adrenal gland, as they can inhibit inflammation pathways and promote wound healing.
1 citations
,
December 2019 in “Frontiers in endocrinology” This study found that high prepubertal and pubertal androgen levels, originating from both adrenal and gonadal secretion, were negatively associated with adult height outcomes in males with Silver-Russell syndrome.
April 2024 in “JCEM case reports” In this case study, a 44-year-old woman with an adrenal adenoma secreting both cortisol and androgens developed Cushing syndrome and significant virilization, but experienced major symptom improvement following surgical removal of the benign tumor.
June 2023 in “Journal of biological chemistry/The Journal of biological chemistry” This study on Sdr16c5/Sdr16c6-null mice found that inactivating these genes significantly increased Meibomian gland secretions and altered lipid profiles but had a subtle impact on sebogenesis, suggesting the genes control a bifurcation point in meibogenesis pathways.
This study found that PRL-1-overexpressing PD-MSCs reduced adipogenesis in orbital fibroblasts from Graves' ophthalmopathy patients by secreting IGFBPs and modulating the FAK pathway.
August 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This article discusses how activating the hexosamine pathway may enhance skin homeostasis by increasing hyaluronic acid secretion and supporting hair follicle stem cell self-renewal, but reports no new results.
May 2004 in “International Journal of Cosmetic Science” This study found that kojic acid and niacinamide were the most effective inhibitors of UVB-induced NF-κB activation and IL-6 secretion in HaCaT keratinocytes, suggesting a role in modulating melanotrophic factor synthesis.
November 2021 in “Elsevier eBooks” This review discusses antiandrogen therapy for polycystic ovary syndrome, focusing on strategies to manage excessive androgen secretion, but it reports no new clinical results.
286 citations
,
June 2012 in “Nature Immunology” In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.
1 citations
,
August 2022 in “Case Reports” This case report describes a woman in her 30s who had virilisation and androgenic alopecia due to a testosterone-secreting ovarian tumor, which normalized after its surgical removal.
January 2025 in “BMJ Case Reports” This case report describes a girl with familial adenomatous polyposis who exhibited heterosexual precocious puberty due to an adrenal tumor secreting cortisol and androgens; after her adrenalectomy, her hormone levels normalized and symptoms improved, illustrating the link between genetic syndromes and endocrine disorders.
January 2019 in “Jui rinsho hifuka” In this case study, a male miniature dachshund with alopecia was diagnosed with estrogen-secreting Sertoli cell tumors and seminoma, with the alopecia resolving post-surgical removal of the tumor.
92 citations
,
September 2019 in “ACS nano” This study observed that a wearable electric stimulation device significantly promoted hair regeneration in rats and mice, outperforming conventional pharmacological treatments and enhancing growth factor secretion.
65 citations
,
December 1986 in “The Journal of Clinical Endocrinology & Metabolism” This study concluded that a 26-year-old woman had autosomal dominantly inherited hereditary cortisol insensitivity, leading to increased adrenocortical cortisol and androgen secretion, which caused clinical symptoms unlike in her male relatives.
53 citations
,
April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.
42 citations
,
September 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS who have an exaggerated 17-hydroxyprogesterone response to buserelin exhibit more severe hyperandrogenemia, increased insulin secretion, and reduced insulin sensitivity.