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This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.

This study found that Cidea is critical for regulating lipid storage and sebum secretion in sebaceous glands, with its deficiency causing hair issues and impaired skin functions in mice.

This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.

This review discusses the potential of mesenchymal stromal cell secretome therapies for facial nerve palsy, emphasizing their standardization advantages over cell transplantation, but provides no new clinical results.

This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.

This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.

In this study, the application of human umbilical cord mesenchymal stem cell secretome significantly increased hair follicle count in fluconazole-induced alopecia in rats, although changes in epidermal thickness were not significant, suggesting a novel approach for hair restoration.

This study suggests that administering SH-MSCs gel might decrease IL-6 expression and increase TGF-β expression in alopecia-like rats, indicating potential for alopecia therapy.

In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.

In this study, researchers developed methods to isolate and culture rat hair follicle stem cells, confirming their potential for skin regeneration by analyzing growth characteristics and bioactive secretions, contributing to regenerative medicine advancements.

This study found that levels of certain signaling proteins were significantly higher in the alopecia zone compared to other areas, suggesting a role in androgenetic alopecia etiology.

This study found that hair follicle stem cell-derived secretome mitigated cell death, apoptosis, and inflammation while upregulating neurotrophic factors in astrocytes exposed to oxygen-glucose deprivation, an in vitro ischemic stroke model, suggesting potential therapeutic benefits in stroke recovery.

This literature review reports that mesenchymal stem cell-derived secretome, including conditioned medium and extracellular vesicles, shows promise as an effective treatment for various diseases in animal and human in-vivo models, with ongoing clinical trials and recommendations for future research discussed.

In this case report, a 48-year-old woman with kerion celsi showed improvement with a regimen including antifungal, bacterial, and adjunctive treatments, though the specific role of mesenchymal stromal cell secretome could not be isolated from the other therapies.

This study found that plucked hair follicles can serve as a practical and scalable source for regenerative medicine, as researchers successfully isolated and expanded keratinocytes and mesenchymal stem cells for potential cell-based and cell-free therapies, demonstrating significant wound-healing bioactivity in vitro.

This study established a method to create stem cell-derived dermal papilla cells and found that their conditioned medium significantly boosts hair growth and offers anti-inflammatory benefits in mice, surpassing minoxidil and addressing androgen-related hair loss.

This study observed that all treatment groups for androgenetic alopecia, using either minoxidil, adipose-derived stem cell secretome, or a combination, showed significant hair growth improvement, with the best results seen in the combination group by week 12, and minimal side effects noted mainly with minoxidil.

This literature review examined research on hair follicle biology and hair loss treatments, highlighting the potential of secretome-based therapies, which may enhance hair regeneration and address limitations of treatments like minoxidil and finasteride.

In this study, a 40-year-old man with hair loss showed complete hair regrowth and no relapse 24 weeks after receiving umbilical cord mesenchymal stem cell and secretome injections, highlighting their potential for alopecia treatment, although further research involving larger populations is needed.

This study found that secretome research in dermatology is growing and has potential for developing novel skin disorder therapies, with collaboration among countries enhancing advancements.

In this study, researchers observed that a topical gel containing 20% hypoxia mesenchymal stem cell secretome significantly reduced IL-15 and IFN-γ mRNA expression and baldness by 60% in male Wistar rats with fluconazole-related alopecia.

In this study, secretomes from hypoxic mesenchymal stem cells were found to increase PDGF and reduce IL-1β gene expression in rats, potentially offering an effective topical treatment for alopecia caused by long-term fluconazole use.

This study found that treatments with adipose-derived stem cell secretome and minoxidil significantly improved hair growth in androgenetic alopecia, with the combination therapy showing the greatest improvement over 12 weeks.

This commentary reviews methods for delivering adipose-derived mesenchymal stem cell secretome for facial skin rejuvenation and does not report new clinical results; the authors discuss addressing concerns about administration methods and product characterization.

This study observed that applying a cream containing secretome from Bovine Umbilical Vein Endothelial Cells promoted healing and regeneration in burn wounds in rats, particularly at a 15% concentration.

Senescent fibroblasts can help start tumors in normal skin cells.

This study found that adipose derived stem cells in areas of alopecia in patients with androgenetic alopecia showed different levels of various signaling proteins compared to other scalp and periumbilical regions.

This article reviews the potential advantages of secretome derivatives from human uterine cervical stem cells in MSC therapy and notes the need for regulatory standards to ensure safety and efficacy.

This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.