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    Did you mean Secreted Frizzled-Related Protein 2?
    Glossary Secreted Frizzled-Related Protein 2

    regulates cell signaling pathways affecting hair follicle development

    Secreted Frizzled-Related Protein 2 (SFRP2) is a protein that plays a role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is crucial for cell growth, differentiation, and development. In the context of hair biology, SFRP2 can influence hair follicle development and cycling, potentially impacting conditions like alopecia.

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    1. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    2. Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles PeerJ · 2019 · 7 citations
    3. Peer Review #2 of "Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles (v0.1)" 2019
    4. Peer Review #1 of "Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles (v0.1)" 2019
    5. Is SFRP-4 an early potential biomarker related to diabetes and hypertension, in patients with androgenic alopecia? Endocrine Abstracts · 2018
    6. Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis Experimental Dermatology · 2015 · 4 citations
    7. Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio Journal of the Pakistan Medical Association · 2024 · 2 citations
    8. Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence Aging Cell · 2026
    9. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    10. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    11. SFRP2 augments Wnt/β-catenin signalling in cultured dermal papilla cells Experimental Dermatology · 2016 · 17 citations
    12. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    13. The role of SFRP1 in human dermal papilla cell growth and its potential molecular mechanisms as a target in regenerative therapy Regenerative Therapy · 2024
    14. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    15. The role of dexamethasone in mediating the contradictory effects of Wnt antagonists SFRP2 and SFRP3 on human hair follicle growth Scientific reports · 2023
    16. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020 · 220 citations
    17. Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-catenin in Inner Mongolia Cashmere Goats Frontiers in genetics · 2021 · 9 citations
    18. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    19. Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells Current Issues in Molecular Biology · 2023
    20. UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO D-Scholarship@Pitt (University of Pittsburgh) · 2018
    21. Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells Scientific Reports · 2026
    22. Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions Research Square · 2026
    23. AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells International Journal of Biological Sciences · 2024 · 5 citations
    24. 174 Dermis-hair follicle communication: Extracellular microvesicles signaling for hair regeneration Journal of Investigative Dermatology · 2020
    25. Expression of the Wnt signaling pathway and hair follicle development in  Rex rabbits of different ages 2025
    26. PAK4 signaling in health and disease: defining the PAK4–CREB axis Experimental & Molecular Medicine · 2019 · 81 citations
    27. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    28. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations
    29. Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways Animals · 2023 · 1 citations
    30. Wnt signaling: the good and the bad Acta Biochimica et Biophysica Sinica · 2008 · 48 citations