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Deleting MPZL3 increases skin oil production and reduces body fat.

Sebum helps protect human skin from microbes.

MEK and BRAF inhibitors increase sebum production and accumulation, which could cause acne-like side effects.

Free fatty acids in sebum boost skin's defense against acne by increasing antimicrobial peptides.

Autophagy is crucial for normal sebaceous gland function and sebum composition.

Increasing sebum production might help reduce fat and improve metabolism.

BB4CMU rice bran oil may help treat hair loss and gray hair.

Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.

Human sebaceous glands can grow back in skin grafts on mice and work like normal human glands.

Eastern Red Bat hair contains various glycerophospholipids, mainly phosphatidylcholine.

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Oral spironolactone and isotretinoin are effective for treating acne.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Improving skin barrier and using antifungal treatments can help manage dandruff.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Botulinum toxin has potential for treating various skin conditions and improving wound healing.

Certain hormone treatments can improve acne and related conditions in women.

Isotretinoin effectively reduces acne but causes dry skin, higher skin pH, more redness, and hair loss.

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Clausena anisata may be effective in treating acne due to its ability to fight bacteria, reduce inflammation, and possibly lower sebum production.

Lower melatonin levels are linked to more skin aging.

The skin has multiple layers and cells, serves as a protective barrier, helps regulate temperature, enables sensation, affects appearance, and is involved in vitamin D synthesis.