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Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

The oral glucose tolerance test is effective in detecting abnormal glucose tolerance in Indian women with PCOS.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride effectively prevents biofilm formation and treats preformed biofilms, but requires high doses.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

Most treatments for spondyloarthritis are safe, but monitoring and careful selection based on patient risks are important.

Nanotechnology improves cosmetics' effectiveness and safety.

Coriander seed oil is safe for healthy adults at up to 600 mg per day.

Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.

The new FDA labeling rules provide more detailed drug safety information for pregnant and breastfeeding women, but more data is needed on the risks of many dermatologic drugs.

Dermatologists play a key role in identifying and documenting signs of abuse and injury for forensic investigations.

Proper mineral supplementation in cow-calf operations prevents health issues and economic losses.

Changing the diet of mice lacking the enzyme CBS can affect symptoms related to the genetic condition.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

The cause of alopecia areata was unknown, and while various treatments existed, no best treatment was agreed upon.

Phenobarbitone can cause severe and sometimes fatal skin reactions.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

Minoxidil works well as a high permeability reference drug for biopharmaceutics classification.

Substance abuse can cause various skin problems, including marks from injections, sores, premature aging, and increased cancer risk.

Hirsutism is common body hair growth due to genetics and hormones, and while not a disease, it can be distressing; virilisation includes hirsutism with other male traits and needs medical attention.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

PCOS is a long-term condition that needs more research for better understanding and treatment.