Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.

The T-zone on the face has more androgen receptors and produces more oil than the U-zone.

This article reviews the occurrence of ectopic sebaceous glands in hair follicle matrix during hair embryogenesis and reports no new clinical results, indicating unknown pathogenesis and clinical implications.

This study investigated the effects of pathological α-synuclein on sebaceous gland cells in Parkinson's disease, finding that α-synuclein exposure altered cellular differentiation and lipid production, suggesting a potential link between α-synuclein and lipid dysregulation in the skin of PD patients.

This review discusses the role of cytochrome P450 enzymes in skin metabolism and drug development for skin diseases, highlighting their importance and suggesting further research, but reports no new experimental findings.

This review discusses Wnt signaling pathways in skin development and stem cell regulation, highlighting potential interactions with other pathways but reports no new findings.

This review discusses the roles and mechanisms of thymosin β4 in hair follicle growth and development but reports no new experimental findings; the authors emphasize the need for further research on its molecular pathways.

This study identifies specific localization patterns of androgen, estrogen, and progesterone receptors in human skin, which could be crucial for understanding their roles in skin biology and pathology.

Recent dermatological research highlights include new virus discoveries, genetic links to skin conditions, and insights into skin healing and pigmentation.

This review highlights recent findings on the importance of signalling pathways in sebaceous gland morphogenesis and differentiation, but reports no new clinical results.

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

In this study, researchers observed that the absence of a functional vitamin D receptor in mice leads to impaired hair follicle regeneration due to defects in keratinocyte stem cells, resulting in alopecia.

This review synthesizes current research on PPAR-γ signaling in hair follicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.

This study found that sebaceous glands can regenerate after PPARg deletion in adult skin, relying on the hair cycle and FGFR signaling.

The authors suggest that the neuroendocrine system of the skin represents a promising target for repurposing drugs, such as cannabidiol and fingolimod, as topical treatments for inflammatory skin diseases.

This review discusses the role of the enzyme Δ9-desaturase-1 in skin lipid regulation and whole-body energy balance in mice and reports no new experimental results.

In this study, Lrig1-positive stem cells in mouse hair follicles were found to be essential for sebaceous gland formation and maintenance, with their depletion causing a temporary loss of these glands and changes in cellular differentiation.

Caspase-3 helps control cell growth and organ size by activating YAP.

This study reports that sebaceous glands can regenerate after injury through stem cell plasticity, with hair-follicle-derived stem cells replacing sebaceous gland progenitors and playing a crucial role in the regeneration process, which is dependent on FGFR2 signaling and aided by hair growth induction.

This study introduced a bioengineered model that simulates acne's microenvironment in mice, enabling the exploration of host and P. acnes interactions and presenting a novel platform for anti-acne drug and vaccine screening.

This study found cell-specific variations in POMC mRNA and peptide expression in murine skin, suggesting that PC1 and PC2 convertases contribute to differential POMC processing.

This review discusses how neuroendocrine regulation affects human hair follicles and suggests potential therapeutic targets, but it reports no new clinical results.

This review discusses the heterogeneity and plasticity of epithelial stem cells in skin homeostasis, wound healing, and tumorigenesis, reporting no new results but emphasizing the need for further exploration of key regulatory mechanisms.

This article describes a method using the CUBIC protocol to clarify and visualize molecular and cellular interactions in mouse skin biopsies at single cell resolution, but does not provide new biological findings.

This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.

In this research, authors found that skin-resident ILCs regulate sebaceous gland function and microbial balance, emphasizing an immune-epithelia system that supports host-microbe symbiosis.

This study found that TGFβ signaling is essential for keeping sebocytes undifferentiated by reducing lipid-related gene expression, using a novel human sebocyte culture model.

This review discusses the role of PPAR-γ in the pathogenesis of primary cicatricial alopecia, including its involvement in lichen planopilaris and treatment trials using PPAR-agonists, and reports no new clinical results.

This study found that Cidea is critical for regulating lipid storage and sebum secretion in sebaceous glands, with its deficiency causing hair issues and impaired skin functions in mice.

This review discusses the role of adipokines in skin physiology and pathology, suggesting they may influence skin conditions and diseases through interaction with various skin cell types, but reports no new clinical results.