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Skin fat helps with body temperature control and has other active roles in health.

The yeast Pityrosporum ovale can cause skin allergies and infections, and antifungal treatments like ketoconazole are effective against it.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

Minoxidil and finasteride treat hair loss; more research needed for other options.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Human hair follicles can make and process prostaglandins, which may affect hair growth.

Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.

Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Antimicrobial lotion reduces inflammation and increases hair density in hair loss patients.

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

Hair proteins have weak spots in their α-helical segments.

Hair loss in male pattern baldness involves muscle degeneration and increased scalp fat.

Pregnancy can cause specific skin conditions that need correct diagnosis and treatment to protect both mother and baby.

Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.

Different tea tree oil mixtures absorb into hair follicles at varying levels, with microemulsion being the most effective.

The arrector pili muscle might play a role in hair loss and needs more research to understand its impact.

Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.

The document concludes that accurate diagnosis and treatment of scalp itch require differentiating between various conditions using a proposed five-step evaluation process.