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Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Stem cell self-renewal is complex and needs more research for full understanding.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Skin fat helps with body temperature control and has other active roles in health.

Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

Skin has specialized touch receptors that can tell different sensations apart.

Smart biomaterials that guide tissue repair are key for future medical treatments.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

The circadian clock influences the behavior and regeneration of stem cells in the body.

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

Androgens slow hair growth by altering Wnt signaling in balding cells.

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

Advanced human skin models improve drug development and could replace animal testing.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.