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TCDD disrupts skin stem cells, causing skin issues like chloracne.

The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

Sebaceous glands are involved in various skin disorders, some treatable with medications like finasteride and minoxidil.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

A woman had a unique skin growth with hair follicle, oil glands, fat cells, spindle cells, and nerve fibers.

Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.

Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.

Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

Proper care and diet are crucial to prevent health issues in gerbils.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Extramammary Paget disease can spread deeply into tissues, reaching up to 3.6 mm.

Researchers found 617 genes that behave differently in cashmere goat hair follicles, which could help understand hair growth.

All-trans retinoic acid at high doses harms goat hair growth cells and could be bad for hair growth.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

Tailored treatment plans are crucial for managing canine dermatomyositis-like disease.

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

Proretinal nanoparticles are a safe and effective way to deliver retinal to the skin.

The document concludes that Hidradenitis suppurativa is often underdiagnosed, lacks definitive treatment, and requires better awareness and management strategies.

Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.