150 citations
,
October 2010 in “The American Journal of Pathology” This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.
December 2025 in “Bioengineering” This review explains that dysregulated sebum secretion and composition contribute to acne and impaired skin barriers while highlighting factors like diet and hormones affecting sebaceous activity, and identifies novel molecular targets and model systems for future therapeutic developments.
April 2008 in “Expert review of dermatology” Mutations in the P2RY5 gene cause hereditary woolly hair.
January 2003 in “Elsevier eBooks” Androgens and other hormones affect hair growth and skin conditions like acne.
19 citations
,
July 2004 in “Clinical and experimental dermatology” This article discusses a case of an adult with acneiform follicular mucinosis that was controlled using systemic corticosteroids and reports no new findings.
7 citations
,
January 2020 in “Journal of Dermatology” This study described specific skin and hair follicle abnormalities in three Japanese patients with Cantu syndrome, which may relate to the regulation role of SUR2 in hair follicle growth.
21 citations
,
December 2007 in “Journal of Investigative Dermatology” This study proposes the sebogenic hypothesis, suggesting that hair follicles evolved from primitive sebaceous glands to facilitate lipid transport and improve water retention in early land-dwelling animals.
4 citations
,
August 2015 in “Medical Hypotheses” This study discusses hormonal changes in gastroesophageal reflux disease that may affect sebaceous gland secretion but does not report new clinical results, suggesting a need for collaborative research in gastroenterology and dermatology.
18 citations
,
June 2012 in “Archives of Dermatological Research” This study found that treatment with vitamin D increased the expression of LL-37 through the vitamin D receptor in cultured sebocytes.
338 citations
,
April 2001 in “Current Biology” This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.
139 citations
,
February 2014 in “Journal of Advanced Research” This review explores the impact of vitamin D deficiency on the skin from a dermatological perspective, but reports no new clinical results.
57 citations
,
August 2002 in “American Journal Of Pathology” Cathepsin L deficiency causes hair and skin issues in mice.
46 citations
,
June 2015 in “Journal of Investigative Dermatology” This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.
32 citations
,
January 2017 in “PLoS ONE” This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.
25 citations
,
October 2007 in “Developmental biology” In this study, transgenic mice altered to express a Clim-inhibiting molecule under a keratin promoter showed corneal degradation and hair follicle failure, highlighting Clim proteins' role in maintaining these tissues.
18 citations
,
October 2014 in “Experimental Dermatology” Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.
9 citations
,
August 2021 in “International journal of molecular sciences” This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.
6 citations
,
July 2017 in “Biochemical and Biophysical Research Communications” This study found that mutations in the hairless gene disrupt normal hair follicle development by impairing Wnt/β-catenin signaling, affecting hair keratinocyte differentiation in both mice and humans.
5 citations
,
October 2020 in “Experimental dermatology” This study reports that during late embryogenesis and early postnatal development, K79-expressing keratinocytes change and die independently of sebaceous glands to form the hair follicle opening, potentially influencing conditions like ingrown hairs or acne.
1 citations
,
June 2017 in “Veterinary dermatology” This case report describes a presumptive case of ichthyosis fetalis in a cross-bred lamb and highlights the need for this rare condition in sheep to be considered by veterinarians in the differential diagnosis of dermatopathies.
September 2004 in “Experimental Dermatology” This paper reviews recent findings on epidermal development and stem cell regulation, listing key studies that contribute to understanding the molecular pathways involved in skin morphogenesis without reporting new experimental results.
53 citations
,
October 1984 in “Endocrine reviews” This review highlights that idiopathic hirsutism is characterized by local hyperandrogenization affecting hair growth, without other signs of hyperandrogenism, and shows no new results; racial differences in prevalence are noted but not in androgenic steroids.
June 2024 in “British Journal of Dermatology” This article traces the historical development of hidradenitis suppurativa's naming and classification, noting that naming disagreements persist despite extensive research.
January 2010 in “Chinese Journal of Aesthetic Medicine” The study observed increased melanin and signs of skin aging in melasma-afflicted skin, with strong CK10 expression in the upper basal epidermis, potentially linked to excessive epidermal cell differentiation and aging.
This article reviews the effects of combined oral contraceptives on skin conditions and suggests prescribing guidelines for women with acne, as it reports no new clinical results.
10 citations
,
October 2017 in “Archivos Argentinos De Pediatria” This study described the range and treatment of skin disorders among pediatric inpatients at a teaching hospital, finding allergic skin diseases as the most common group, primarily diagnosed clinically.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that tissue transglutaminase (TG2) may play a role in sebum production by regulating autophagy in sebaceous glands, offering potential targets for dermatological interventions.
97 citations
,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.
3 citations
,
June 2024 in “International Journal of Molecular Sciences” In this review, the potential role of the hormone prolactin in skin biology and its implications for treating skin diseases and hair disorders are explored, with a focus on its stress-related impacts and possible immunomodulatory function in the context of COVID-19.
36 citations
,
January 2023 in “Skin Appendage Disorders” This review discusses the etiology, pathophysiology, trichoscopic characteristics, differential diagnoses, and treatment options for scalp seborrheic dermatitis, without providing new clinical findings.