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Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

Better hair care products are needed to protect against grooming and chemical damage.

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.

Damaged hair follicle stem cells can cause permanent hair loss, but understanding their role could lead to new treatments.

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

Loss of Fz6 disrupts hair follicle and associated structures' orientation.

Photodynamic Therapy is an effective treatment for mild to severe acne.

Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.

The skin and thymus develop similarly to protect and support immunity.

The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.

Nanoparticles effectively deliver water-insoluble drugs to hair follicles, stimulating hair growth without irritating the skin.

A hydrogel made from pig fat helps wounds heal faster by regenerating skin fat cells.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

Llamas often have skin issues like mange, bacterial infections, and allergies, with some treatable by zinc.

The review concludes that accurate diagnosis of different types of hair loss requires proper biopsy techniques and understanding the hair growth cycle and underlying causes.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

The T-zone on the face has more androgen receptors and produces more oil than the U-zone.

Telocytes in the scalp may help with skin regeneration and maintenance.

Androgen receptors found in monkey scalps, similar to humans, affect hair growth.

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

Topical antiandrogens might treat skin issues like hair growth, balding, and acne, but finding effective treatments without side effects is challenging.

Transfollicular drug delivery is promising but needs more research to improve and understand it better.