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    Glossary SCUBE3

    SCUBE3 (Signal Peptide, CUB Domain, EGF-like 3) is a protein that plays a role in various biological processes, including cell signaling and tissue development. In the context of hair biology, SCUBE3 has been implicated in the regulation of hair follicle development and cycling, influencing hair growth and regeneration. Its relevance to hair loss lies in its potential involvement in the mechanisms that govern hair follicle stem cell activity and the overall health of hair follicles, making it a subject of interest in research on hair loss treatments and therapies. Key distinguishing characteristics of SCUBE3 include its structural domains, which facilitate interactions with other proteins and signaling pathways critical for hair follicle function.

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    Research 26

    1. Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse Gene Expression Patterns · 2006 · 17 citations
    2. Characterization of a mouse Scube3 reporter line Genesis · 2010 · 7 citations
    3. Ageratum houstonianum Extract and Agerarin Promote Hair Growth via MAPK/AP-1 Axis-Dependent Upregulation of SCUBE3 in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2026
    4. Signal Peptide-CUB-EGF-like Domain-Containing Protein 3 (SCUBE3): From Molecule to Therapy Therapeutics · 2026
    5. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    6. Stem Cell Applications in Human Hair Growth: A Literature Review Cureus · 2023 · 8 citations
    7. Wasabi leaf extract changes the expression levels of cytokine related genes in dermal papilla cells, which identified by the whole transcriptome 2025
    8. Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment PLoS ONE · 2021 · 24 citations
    9. Hair Dermal papilla maintain its hair inducing characteristics via autocrine exosomal miR-23a-3p 2025
    10. Glypican-1, -4 and 6 Participate in the Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7 and Patched 1 SPIRE - Sciences Po Institutional REpository · 2024
    11. Modelling androgen synthesis and action during human sexual differentiation ePrints Soton (University of Southampton) · 2010
    12. Multiple cell types guided by neurocytes orchestrate horn bud initiation in dairy goats Genetics Selection Evolution · 2025 · 1 citations
    13. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015 · 173 citations
    14. Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness Frontiers in Genetics · 2024 · 10 citations
    15. Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation Autophagy · 2023 · 2 citations
    16. Pu‐erh tea reduces the transmission of CRD‐mediated alopecia risk to offspring Food Frontiers · 2024 · 1 citations
    17. Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway International Journal of Molecular Sciences · 2026
    18. Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives Stem Cell Research & Therapy · 2025
    19. Mapping Human Skin: One Sequenced Cell at a Time 2023
    20. Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness Animals · 2023
    21. Self-Assembled Peptide Hydrogels in Regenerative Medicine Gels · 2023
    22. Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice Food frontiers · 2023
    23. Parsing patterns: Emerging roles of tissue self-organization in health and disease Cell · 2024 · 22 citations
    24. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation Science advances · 2023 · 3 citations
    25. Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis 2023 · 1 citations
    26. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022